Dream Basement Finishing Project - Lakeville MN
This is a basement finishing project near Lakeville, MN. In Credit River Township. It has a full bar, movie theater room, family room and pool table area! Yes, it is the DREAM basement! Basement finishing, bathrooms remodeling, additionsFrom:creativecarpentrymnViews:1 0ratingsTime:01:21More inEducation
Read more here:
Dream Basement Finishing Project - Lakeville MN - Video
Deck Repair
Chuck Horne of Compass Home Improvement Remodeling shows us how to repair a deck.From:LifeCoach321Views:0 0ratingsTime:10:03More inHowto Style
Go here to see the original:
Deck Repair - Video
Lunch Learn Events in Florida Builder Appliances, short promo from Chef Rachelle Boucher
kitchenandplumbing.com Comprised of three brands with distinctive showrooms spanning across four major markets, we are the premier supplier of home appliances. Standards of Excellence in California and Northern Nevada, Westar Kitchen and Bath in Arizona and Florida Builder Appliances throughout Florida service the needs of the building, remodeling and interior design industry, as well as homeowners alike. Each of our showrooms prides itself on providing outstanding customer service beginning with product selection, education, delivery and installation.From:kitchenandplumbingViews:0 0ratingsTime:00:19More inHowto Style
See original here:
Lunch
Kitchen Counter-Tops Richmond, VA (804) 461-3939
http://www.kitchenandbathrenovations.net Richmond and Petersburg, VA. Kitchen Bath Renovations is a full service remodeling contractor. We offer the best selection of quality kitchen and bath components. From cabinets and counter tops to sinks, tubs, faucets, lighting, and flooring mdash;we will help you from the design to the completion of your project.From:KitchenRemodelingVAViews:0 0ratingsTime:00:37More inEducation
Continue reading here:
Kitchen Counter-Tops Richmond, VA (804) 461-3939 - Video
Home Renovations Richmond, VA (804) 461-3939
http://www.kitchenandbathrenovations.net Richmond and Petersburg, VA. Kitchen Bath Renovations is a full service remodeling contractor. We offer the best selection of quality kitchen and bath components. From cabinets and counter tops to sinks, tubs, faucets, lighting, and flooring mdash;we will help you from the design to the completion of your project.From:KitchenRemodelingVAViews:0 0ratingsTime:00:36More inEducation
Original post:
Home Renovations Richmond, VA (804) 461-3939 - Video
Remodeling Ampeds Base | MC | FEARPVP |
Destroying an enemy base on Fear PvP. IP is play.fearpvp.net DISCLAIMER: I do not in any way own MinecraftFrom:TheMisterVintageViews:0 0ratingsTime:00:46More inGaming
Dig-it - Remodeling - 034
This is a minecraft server I started for friends and family. Please don #39;t ask to join. ~~~~~~~~~~~~~~~~~~~~ Twitter: twitter.com Facebook: fb.me Minecraft: minecraft.net ~~~~~~~~~~~~~~~~~~~~ Royalty Free Music by audiomicro.com Sound Effects by audiomicro.comFrom:bigougitViews:1 1ratingsTime:22:53More inShows
Originally posted here:
Dig-it - Remodeling - 034 - Video
The Wallis Project
The Wallis Project - http://www.StructEnv.com Office 512-809-1609 ; Complete Remodel Project. Architectural Design by AIA Architect Nana Kim http . Landscape Design Build by Robert Leeper http://www.robertleeperdesigns.com Architectural Essays and Compositions structenv.com , New Construction, Remodeling, Commercial, Residential Austin, Texas; Complete Bathroom Kitchen Remodels, Bullet Proofing Windows Walls, High Surveillance Security Systems and Special Unique Custom Homes or Office Buildings, visit http://www.StructEnv.com Structural Environments Architecture Design Build AIA Associate ConstructionFrom:1cyberone1Views:0 0ratingsTime:05:25More inEducation
Go here to see the original:
The Wallis Project - Video
Remodeling Tips 6-10
http://www.RigleyRealtyGroup.com West Sacramento Homes for Sale, West Sacramento Realtor Mike Jennifer Rigley discuss West Sacramento Home Values West Sacramento Real Estate Blog -- Top 10 Remodeling Myths -- 6-10 West Sacramento Realtor and West Sacramento Area Specialists Mike Jennifer Rigley here bringing you the latest West Sacramento Real Estate Information. Thank you for joining us. Today let #39;s talk about the top 10 remodeling myths 6-10. 6. Adding a bedroom is better than adding a bathroom. It depends on the starting point. If you only have one or two bedrooms to start with, adding a bedroom before adding a second bath is probably a wise choice since most buyers are more attracted to a three bedroom home. On the other hand, if you already have three bedrooms and only one bath, your next investment would probably be in a new bathroom. 7. Paint hides a multitude of sins. Dry rot? Fungus damage? Mold problems? Carpenter ants? Termite issues? Nothing a can of paint can #39;t fix, right? Wrong! Not only does this practice violate disclosure laws in most states, it can set you up for liability after the sale as most buyers will want you to foot the bill for these hidden issues. 8. Converting a garage to living space is a great trade off. Nope. A garage conversion is almost always viewed negatively by future West Sacramento home buyers unless you replace the lost garage with another space of equal size (but then what #39;s the point?). If you are going to do one anyway make sure ...From:WestSacHomeSalesViews:0 0ratingsTime:03:12More inPeople Blogs
See the article here:
Remodeling Tips 6-10 - Video
ScienceDaily (Nov. 13, 2012) Max Planck researchers are investigating the signalling pathways via which the smooth muscle cells of blood vessels react to extracellular changes.
Blood vessels are extremely dynamic: depending on the external conditions, they can adapt their permeability for nutrients, their contractility, and even their shape. Unlike cardiac muscle cells, for example, the smooth muscle cells in blood vessels demonstrate a high degree of plasticity, so they can specialise or multiply as required, even repairing damage to the vessel wall. This vascular remodelling is evidently precisely regulated. Disruptions are extremely significant in conditions such as atherosclerosis or high blood pressure. At the Max Planck Institute for Heart and Lung Research in Bad Nauheim, scientists conducting research on genetically modified mice have discovered how external signals regulate vascular remodelling at cell level. This has created an entirely new understanding of regulation, which could pave the way for new approaches in the prevention and treatment of atherosclerosis and other vascular diseases.
The walls of blood vessels consist of smooth muscle cells, elastic fibres, and endothelial cells, which line the interior surface of the vessel. The vessels change their permeability and contractility as required. If a blood vessel is damaged, existing smooth muscle cells can give rise to new specialised muscle cells to repair it. However, in the case of a vascular problem, this necessary and useful cell plasticity can have negative consequences. For example, if a coronary blood vessel is opened up with dilatation and stents via a catheter, muscle cell growth may cause it to narrow once again. In the common condition atherosclerosis or vascular calcification, too, remodelling processes lead to formation of the dreaded plaque. All these processes are regulated by hormones or neurotransmitters, some of which are released by cells and nerves in the vessel wall. Most of these vasoactive messengers work by binding to receptors, which in turn, once activated, bind to what are known as G proteins. These are situated on the inside of the cell membrane and relay the signal from there into the cell interior.
"There are two different families of G proteins which play a crucial role in vascular remodelling. They are called Gq/G11 and G12/G13 after their protein components," explains Max Planck scientist Stefan Offermanns, who has been researching these proteins and their molecular signalling pathways for several years now. In the latest study on genetically modified mice, the team was able to demonstrate for the first time how, in a living animal, these two signalling pathways are regulated by messengers. "Contrary to expectations, the two G protein-mediated signalling pathways antagonistically regulate the plasticity of smooth muscle cells," says Offermanns, summarising the findings. This is surprising in that these signalling pathways act together in other contexts: stimuli that promote vessel contraction and thus increase blood pressure activate both signalling pathways in parallel.
In order to investigate the signalling pathways and their regulation, Till Althoff, who headed the study, examined mice whose genes for the various G proteins he had specifically deactivated. Thus the researcher was able to show, for example, that in a mouse suffering from atherosclerosis and missing G12/G13 in the smooth muscle cells, these cells begin to grow excessively -- the result was a considerably thickened vessel wall. By contrast, animals lacking a Gq/G11 protein were protected against this thickening of the cell wall.
"We see here clearly that in vascular remodelling the two signalling pathways work as antagonists," Offermanns explains. Which is only sensible, as it is the only way a system can balance cell growth and regression. In further tests, the scientists also demonstrated the steps required for the two pathways to achieve their objective and stimulate the genes in the cell interior responsible for generating specialised cells or for cell growth.
"Our results really do reveal a completely new picture of the regulation of vascular remodelling, also in pathological processes," says Offermanns. The researchers are therefore hopeful that new pharmacological approaches can be developed. Offermanns can well imagine, for example, that drugs could be used to modulate plasticity in cases of vascular diseases like atherosclerosis or after cardiological interventions. Now that the target structures in both signalling pathways have been identified, new possibilities are opening up. For instance, the pathway that promotes growth could be blocked and the stabilising pathway activated in order to slow down the remodelling process. "In animal models we are already investigating new therapeutic approaches to preventing atherosclerosis and suppressing cell growth in damaged vessels," reports Offermanns.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
Read more from the original source:
G proteins regulate remodeling of blood vessels