Merry Christmas From Triple S Remodeling!

By: Precigen Solutions LLC.

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Merry Christmas From Triple S Remodeling! - Video

Military Family Receives Remodeling
2014 - An Army family of nine had their basement remodeled for the Holidays by Home Service Solutions Group. http://www.dvidshub.net/video/383982/military-family-receives-remodeling.

By: DoD News

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Military Family Receives Remodeling - Video

1983 Fleetwood Tioga Final Day of remodeling and repairs
It took a long time and a bit of money and long hours on weekends. Sealed rubber roof,Rebuilt carburetor, changed plugs, fuel filters,air filter, diagnosed no start, stall and fuel system failures,...

By: D Haines

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1983 Fleetwood Tioga Final Day of remodeling and repairs - Video

A surprise finding that complicates remodeling for Regency Park Elementary School is giving the Plum School Board pause.

Fifty-year-old drawings of the school indicated 200 feet of crawl space below the first floor.

Construction officials had planned during the school's construction and remodeling project to run utility lines from the space and throughout the two-story building.

Officials got an unpleasant surprise recently when they found out during an inspection that just a partial crawl space exists, L.R. Kimball project manager Steven Ackerman said during last week's school board meeting. Ackerman said an inspection of the area showed a partial crawl space along with a concrete floor and gravel.

The plan was to gut the building and run new lines from below (in the crawl space), Ackerman said.

Ackerman said that unlike today, building drawings 50 years ago were not done after a construction project was completed.

The Plum School Board in October voted to borrow $10 million for the project, which is expected to cost between $7.9 million and $9.3 million.

Board members discussed both remodeling and adding on to the building and building a new school. Ultimately, they decided to remodel and add on to the school.

The work is expected to begin in June and be completed for the start of the 2016-17 school year. Students will attend classes at the current Holiday Park Elementary School after its students move into their new building.

The project manager said the next step will entail Pennsylvania Soil and Rock drilling into the area where the crawl space exists to measure it and learn more about it. The work is expected to occur during Christmas break.

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Plum School Districts Regency Park renovation may need to be tweaked

Tuesday, December 23, 2014 | 6:00 p.m. CST; updated 9:40 p.m. CST, Tuesday, December 23, 2014

COLUMBIA After 1 years of remodeling, Arch and Column Pub will have a grand reopening Dec. 31, showing off its freshly painted walls, refinished bar, new TVs and repaired plumbing.

"I expect this place is going to be jammed," owner Pitt Potter said. "Were going to overflow onto the patio without a doubt."

Arch and Column has helped local charities, such as Trail to a Cure, an HIV/AIDS research fundraiser, by raising money through various activities and shows.

"Its become a community center," Potter said. "Everybody gets treated very well here. It certainly started out as catering to the gay community, but as people found out, we welcomed everybody."

Arch and Column, 1301 Business Loop 70 E., originally opened on New Year's Eve in 2002. It closed in July 2013 for renovations. Shortly after closing, Potter realized he had more work to do than he anticipated.

To fund the renovations, long-time friends and patrons Jesse Graham and Billy Granneman created the Arch and Column GoFundMe page on Dec. 7, and Potter's partner, Mark Wadley, helped get additional financing.

According to information on the page, Potter struggled with attention deficit hyperactivity disorder, which made it difficult for him to complete projects.

"There were a whole bunch of projects that I had started but not finished, so it was a state of overwhelm for me," Potter said.

The page has served as a way to allow contributions for the final renovation phase from people who could not visit the bar in person, Graham said. So far, $940 has been raised with a goal of $1,800.

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Closed for remodeling since July 2013, Arch and Column will open to ring in new year

How To Keep Your Pet Safe During Remodeling
http://PCIN.TV Pet safety during construction is a number one priority for homeowners but many don #39;t realize how their furry friends will behave. Having new ...

By: Phoebe Chongchua

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How To Keep Your Pet Safe During Remodeling - Video

6 Smart Home Remodeling Tips
Looking to remodel your home but are unsure of what is necessary and what is a complete waste of money? Not to worry - here are 6 smart home remodeling tips to help you get the most bang for...

By: Eric Heidt

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6 Smart Home Remodeling Tips - Video

The Delray Sands Resort on Highland Beach has completed the remodeling of rooms and public spaces, operator Ocean Properties Ltd announced Thursday.

The 115-room oceanfront resort at 2809 S. Ocean Blvd. now offers ocean-inspired guest rooms and suites, and oceanfront meeting and event space.

The upgraded guest rooms feature mini refrigerators, in-room coffee makers, premium cable channels and other amenities.

"Beyond the new lobby and their guest rooms, our guests will even be able to experience this ocean inspiration on the menu at Latitudes," said Andy Berger, Ocean Properties vice president of operations, in a statement.

Latitudes the resort's new oceanfront restaurant and lounge offers menus featuring farm-to-table selections and a combination of new and classic seafood dishes. The restaurant boasts five social and dining spaces, including a main dining room, outdoor terrace, Wave Pool Bar and areas for private social events.

For information, go to DelraySandsResort.com or call 866-790-2198.

asatchell@sunsentinel.com, 954-356-4209 or Twitter@TheSatchreport

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Delray Sands Resort completes remodeling

Remodeling your home with a reasonable budget PBL Project 2014-2015
This is a video about how to remodel a home with a reasonable budget. This is a school project that I have personally conducted. Thanks for watching this video! Like, Subscibe, and leave a...

By: Maram Albar

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Remodeling your home with a reasonable budget PBL Project 2014-2015 - Video

Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, i.e., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes.[1] Besides actively regulating gene expression, dynamic remodeling of chromatin imparts an epigenetic regulatory role in several key biological processes, e.g., DNA replication and repair; apoptosis; chromosome segregation as well as development and pluripotency. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.

The transcriptional regulation of the genome is controlled primarily at the preinitiation stage by binding of the core transcriptional machinery proteins (namely, RNA polymerase, transcription factors, and activators and repressors) to the core promoter sequence on the coding region of the DNA. However, DNA is tightly packaged in the nucleus with the help of packaging proteins, chiefly histone proteins to form repeating units of nucleosomes which further bundle together to form condensed chromatin structure. Such condensed structure occludes many DNA regulatory regions, not allowing them to interact with transcriptional machinery proteins and regulate gene expression. To overcome this issue and allow dynamic access to condensed DNA, a process known as chromatin remodeling alters nucleosome architecture to expose or hide regions of DNA for transcriptional regulation.

By definition, chromatin remodeling is the enzyme-assisted process to facilitate access of nucleosomal DNA by remodeling the structure, composition and positioning of nucleosomes.

Access to nucleosomal DNA is governed by two major classes of protein complexes:

Specific protein complexes, known as histone-modifying complexes catalyze addition or removal of various chemical elements on histones. These enzymatic modifications include acetylation, methylation, phosphorylation, and ubiquitination and primarily occur at N-terminal histone tails. Such modifications affect the binding affinity between histones and DNA, and thus loosening and tightening the condensed DNA wrapped around histones, e.g., Methylation of specific lysine residues in H3 and H4 causes further condensation of DNA around histones, and thereby preventing binding of transcription factors to the DNA leading to gene repression. On contrary, histone acetylation relaxes chromatin condensation and exposes DNA for TF binding, leading to increase gene expression.[2]

Well characterized modifications to histones include:[3]

Both lysine and arginine residues are known to be methylated. Methylated lysines are the best understood marks of the histone code, as specific methylated lysine match well with gene expression states. Methylation of lysines H3K4 and H3K36 is correlated with transcriptional activation while demethylation of H3K4 is correlated with silencing of the genomic region. Methylation of lysines H3K9 and H3K27 is correlated with transcriptional repression.[4] Particularly, H3K9me3 is highly correlated with constitutive heterochromatin.[5]

Acetylation tends to define the openness of chromatin as acetylated histones cannot pack as well together as deacetylated histones.

However there are many more histone modifications, and sensitive mass spectrometry approaches have recently greatly expanded the catalog.[6]

The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends. Together with similar modifications such as DNA methylation it is part of the epigenetic code.

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Chromatin remodeling - Wikipedia, the free encyclopedia