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    Once flooded by Harvey, the new home of AIA Houston and the Architecture Center is almost open – Laredo Morning Times

    - October 20, 2020 by Mr HomeBuilder

    Rusty Bienvenue, executive director of both the AIA Houston and the Architecture Center Houston, poses at the reception desk in the newly renovated center, which is home to AIA Houston. Renovations on the site -- a historic downtown building -- were nearly complete in 2017 when Hurricane Harvey flooded it. They had to start completely over, including installing more flood mitigation.

    Rusty Bienvenue, executive director of both the AIA Houston and the Architecture Center Houston, poses at the reception desk in the newly renovated center, which is home to AIA Houston. Renovations on the site

    Photo: Gary Fountain, Houston Chronicle / Contributor

    Rusty Bienvenue, executive director of both the AIA Houston and the Architecture Center Houston, poses at the reception desk in the newly renovated center, which is home to AIA Houston. Renovations on the site -- a historic downtown building -- were nearly complete in 2017 when Hurricane Harvey flooded it. They had to start completely over, including installing more flood mitigation.

    Rusty Bienvenue, executive director of both the AIA Houston and the Architecture Center Houston, poses at the reception desk in the newly renovated center, which is home to AIA Houston. Renovations on the site

    Once flooded by Harvey, the new home of AIA Houston and the Architecture Center is almost open

    For seven years now, Rusty Bienvenue has been steeped in issues of construction, engineering, raw materials, fund raising, insurance and grant applications. He never imagined hed have to seek advice on flood mitigation, navigate intricate insurance channels or search for the best acoustician he could find.

    Late in the summer of 2017, Bienvenue, executive director of both the Architecture Center Houston and the Houston chapter of the American Institute of Architects, and his staff were just a few weeks away from moving into their new home in the historical B.A. Reasoner Building after a lengthy and intricate buildout.

    What: virtual home tour using videos of 15 home projects by Houston architects

    When: Oct. 24

    Where: AIAHoustonhometour.org

    Cost: free

    Like much of downtown, the building was flooded by Hurricane Harveys relentless rain that left 4 feet of water in what was to be the centers new home at 900 Commerce. Originally known as the B.A. Reasoner Building, it went up in 1906, just a block from the historical marker that recognizes Allens Landing, where the Allen brothers founded the city of Houston.

    AIA Houston and the Architecture Center are separate organizations but are intricately linked, as AIA Houston makes its home in the center. For a decade, they had saved money from programs and galas to pay for their $1.3 million building and its initial $950,000 renovation.

    Hurricane Harvey sent them back to the drawing board, having to start over and incorporate more flood mitigation, all of which cost $1.6 million. Though they had flood insurance, their settlement with FEMA was a mere $248,000, leaving them on the hunt for grants including some from the Brown and Elkins Foundations and the Downtown Management District and other donations.

    MORE FROM DIANE COWEN: Texas architects help Houston couple build modern farmhouse in Washington County

    AIA Houston had its own competition to determine which local architecture firm would reimagine the space, and Murphy Mears Architects won; Cardno and Walter P Moore handled engineering.

    Bienvenue and his staff will move in at the end of October, and on Nov. 9 the 5,400-square-foot center will debut its first exhibit by reservation only and in very small groups Houston 2020 Visions, an exhibit about flooding, resiliency and the citys future. Already it is online at Houston2020Visions.org.

    We own it and feel like it could be a model of resilience strategy for how you live in a floodplain, Bienvenue said of the new Architecture Center Houston. We think its unethical and immoral to abandon old buildings if you can figure out how to save them.

    On Oct. 24, the groups annual home tour will be conducted virtually online at AIAHoustonhometour.org. The tour is one of the citys most prestigious, a juried collection of homes designed by local architects and open to the public.

    This years tour, however, is virtual and includes videos of 15 homes, most of which are local. There are a few country homes and one in Australia, but they all represent the work of Houston architects.

    They include a tiny home, others on the small side and some that are considerably larger and more luxurious. A video of New Hope Housing, an award-winning apartment building for those with very low income, is included.

    Bienvenues tour of the new Architecture Center still shows some work to be done, but its mostly cleanup. The concrete floors will be sealed and polished, but speckles of darker aggregate in the mix show through.

    Most of the cast-in-place concrete walls will remain bare, though some have plaster and a couple have drywall. One of those is a panel with drywall front and back installed on a track that moves through the main exhibit space.

    MORE FROM DIANE COWEN: First look: Houstons Giorgetti building makes a sleek statement

    The new Architecture Center Houston, home of AIA Houston, is in the B.A. Reasoner Building, built in 1909.

    The new Architecture Center Houston, home of AIA Houston, is in the...

    Flood mitigation measures installed beyond their first buildout include exterior steel panels with caulking, round plugs in the floor that would pop up to relieve hydrostatic pressure should floodwater come from underneath the building and a protective bathtub in the center of the main space.

    Its meant to withstand 8 or 9 feet of water, allowing some to go in to protect the buildings structure. Bienvenue explained that the pressure of floodwater on a water-tight building would cause the walls to collapse. Allowing some water in causes damage but prevents destruction, he said.

    That bathtub or submarine, as Bienvenue calls it, is a watertight, bunker-like cube in the center, with flood doors to keep its contents dry and safe. Its where the computers and equipment are located, so they wouldnt be ruined in flooding.

    The main part of the centers space is for exhibits a big open room with concrete floors and walls and smaller tracks in the ceiling from which exhibit panels could hang.

    A reception desk near the center bathtub was pushed back to be more welcoming, inviting people in instead of stopping them at the door. Its a work of art on its own, a Murphy Mears design with a Corten steel envelope fabricated by artist George Sacaris on a wooden base created by Brochsteins, a Houston firm known for its fine woodwork and cabinet making.

    Meeting space on the side has panels that can open or close to allow one large space or two smaller rooms; its furniture is on wheels and modular so it can be reshaped to any groups need.

    One of the biggest visual changes is the lack of drywall. The Harvey flooding caused the architects to rip out drywall everywhere. In their second go-around, drywall was kept to a minimum for easier cleanup in case of future flooding.

    There are also interesting panels on the ceiling, with beveled holes cut in what looks like a celestial pattern. Theyre simply plywood panels painted white, with the holes cut both to allow light to come through and to maximize acoustics. Bienvenue said the panels manage sound so well that events wont even require microphones.

    The Houston 2020 Visions exhibit will be the next event held here, and when the coronavirus pandemic has waned enough, Bienvenue said that AIA and the Architecture Center hope this can be a venue for other groups.

    Its built for architecture and design, and well define that broadly. We dont mind if parties and weddings are held here, Bienvenue said. We want the space to be activated.

    diane.cowen@chron.com

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    Once flooded by Harvey, the new home of AIA Houston and the Architecture Center is almost open - Laredo Morning Times

    5 tiny offices that let you work from your own backyard – Insider – INSIDER

    - October 20, 2020 by Mr HomeBuilder

    Before the coronavirus pandemic hit the US, working from home was seen by some as a once-in-a-while luxury, something you had to clear with supervisors to make sure your work production didn't suffer. But since mid-March, millions of people have been working remotely from home. Now, companies like Dropbox and Microsoft are letting their employees work from home permanently, and many other companies are considering letting employees continue to work from home after the pandemic.

    For some, the transition to working from home was seamless and even benefited their mental health, but for others, trying to balance family life and work life under one roof has been challenging. Enter backyard offices, the newest trend in the tiny living world hoping to spice up the work-from-home game.

    With companies looking for an alternative to office space and people in need of a new home office, here are five tiny office companies around the world offering a fresh perspective on working from home.

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    5 tiny offices that let you work from your own backyard - Insider - INSIDER

    Behind the scenes of Butler’s science complex construction – The Butler Collegian

    - October 20, 2020 by Mr HomeBuilder

    The first phase of construction will be complete by fall 2021. Photo by Meghan Stratton.

    MEGHAN STRATTON | EDITOR-IN-CHIEF | mrstratt@butler.edu

    Since breaking ground over a year ago, the massive, cordoned construction zone between Gallahue Hall and the Holcomb Building has given way to a brand-new connector building and the beginnings of a glittering glass atrium. The 96,000-square-foot project is the result of over ten years of planning, and as the metal framework grows every day, Butlers vision for a cutting-edge new science complex is coming to life.

    There were several different groups involved in the initial project proposal, but it wasnt until June 2019 that the Board of Trustees officially approved the plans. LuAnne McNulty, associate dean and chemistry department chair, said she and Jay Howard, dean of the college of liberal arts and sciences, were on pins and needles awaiting the results of the Boards decision.

    And I think, for days, both of us just walked around on a cloud of air because it was so exciting, McNulty, also a chemistry professor, said. And it was also, I think, for a lot of people, kind of an emotional moment, because so many of us came here and have been working in these facilities that we were told would be eventually upgraded. And so when it finally happened, it was just like, Oh my gosh.

    After the announcement, Butler worked to solidify its plans and divided the construction process into three phases. Phase I will be completed in fall 2021, and the construction of the remaining two phases is on track to be completed by 2023. The project will add 11 classrooms of different sizes, the largest of which will be able to seat 75 students. Additionally, the complex will provide dedicated spaces for biology, chemistry, psychology, physics and engineering dual degree program majors.

    Butler is hoping to raise $42 million of the $100 million renovation budget from donors. Meagan Burton-Krieger, development officer for university advancement, said donors have already contributed around $30 million in gifts and commitments.

    The beauty of that is that we have so many passionate alumni and friends who are into what this building will mean, both to our students and our faculty but also to the city and to the industry around town, Burton-Krieger said.

    Phase I

    Phase I of the science complex construction project focuses on connecting Gallahue Hall and the Holcomb Building through the creation of a new connector building. This building will house classrooms, private study areas, a completely renovated science library, research labs and common spaces.

    The buildings central focus is a large glass atrium, which is currently in the final stages of installation and completion. The atrium will serve as a common collaboration space, designed for students to casually socialize or to gather for larger assemblies like poster sessions and guest speakers.

    Burton-Krieger said this space is designed intentionally; the science departments have traditionally struggled to figure out where to hold these types of events, as there is currently no large gathering space located near the science buildings.

    The new science complex will feature an atrium with glass windows. Photo by Xan Korman.

    Furniture for the atrium, which is currently being finalized, will include several small tables and chairs for gathering, as well as larger couches and individual chairs by the windows. Toward the west end, the atrium will also feature risers for students to gather on, as part of the Fenneman Gateway donor space.

    Construction has begun on the risers that students will be able to gather on. Photo by Xan Korman.

    Once completed, the risers will look similar to depiction in the renderings. Rendering courtesy of Butler University Office of Advancement.

    The second floor of the connector building will hold the newly-renovated science library, which is now one floor instead of two. The library will feature a back wall made entirely of glass windows, collaborative group study spaces and individual study hubs. The science library is scheduled to open in March 2021, but the details of how students will enter amid construction is still being determined.

    There are a couple of ways in, so were just trying to figure it out at that point with where we are construction wise, Burton-Krieger said.

    The complex will feature a renovated science library. Photo by Xan Korman.

    The renovated science library will feature study spaces for groups and individuals. Rendering courtesy of Butler University Office of Advancement.

    Next to the science library, there will be a classroom computer lab. There will also be a study space walled off by glass, similar to the Lacy School of Business Innovation Commons. Additionally, on the second floor there will be a classroom with a retractable glass wall meant to accommodate both open and closed environments, depending on the need. Burton-Krieger said this points back to the idea of collaboration within the sciences.

    In the complex, there will be a classroom with a retractable glass wall for open and closed environments. Rendering courtesy of Butler University Office of Advancement.

    NcNulty said the research and teaching labs were designed with the future of science in mind. Even if science changes drastically in the next 20 years, McNulty said the facilities were designed to be changeable which translates to the implementation of pod seating and moveable coursework.

    Construction has begun on chemistry and biochemistry resources and classrooms within the complex. Photo by Xan Korman.

    New biochemistry research labs will be included in the new complex. Rendering courtesy of Butler University Office of Advancement.

    The

    The science complex will also feature new organic chemistry labs. Rendering courtesy of Butler University Office of Advancement.

    Phase I of the construction process has not come without outside influences: first, the COVID-19 pandemic hit in March and sent students home from campus. However, Eric Zeronik, senior superintendent at Pepper Construction of Indiana, said the pandemic has not had a big impact on the construction.

    We were back here on our own and able to work, not outside of the limits or anything, but we were able to take advantage of a quiet campus, Zeronik said.

    Despite the pandemic, the project is still on schedule for the original 2023 completion date, although the company did see a few minor delays for materials like glass. The construction project is essentially following the same health policy as Butler: workers are required to do a health check with temperature monitoring each day. Zeronik said they have only had about five workers self-quarantine, but that there havent been any positive COVID-19 cases on the project.

    Pepper Construction is also currently priming to conduct construction in the cold winter months. To prepare, they are currently completely renovating the Holcomb Building roof and adding drywall to the connector building at a rate of 170 drywall sheets per day. Zeronik said the construction company is in the process of getting air handler units, what he calls the heart and lungs of the building, so the project will have hot air for the winter.

    We have it to the point now where the main structure is up, were really getting the envelope buttoned up for the winter, Zeronik said. So when the colder weather comes in, well be dry.

    Phase II

    After the connector building is completed for fall 2021, the construction will shift focus to renovating and repurposing the Holcomb Building. The first floor of Holcomb will house the psychology major and neuroscience minor departments, while the physics department will be on the second floor. Finally, Butlers IT department and the dual-engineering program will be located on the third floor.

    The Holcomb renovation will add classrooms and research labs in addition to common work spaces. Holcomb was the previous home of the Lacy School of Business until fall 2019, and thus the entire construction project needed to wait until the business school moved into their new building.

    Phase III

    After Holcomb is completely renovated, Gallahue Hall will be the next construction focal point. The biology and microbiology departments will be housed in the basement and ground floor of Gallahue, and the chemistry and biochemistry departments will occupy the second and third floors.

    There will be several added classrooms and research labs in Gallahue as well. Specifically, one lab on the second floor will be dedicated to biochemical research.

    It really is an interdisciplinary space Burton-Krieger said. Theres going to be a research space in there that really puts faculty who work together on the same topic together, versus by discipline.

    Additionally, the current auditorium in Gallahue will receive considerable renovations and refreshments to the space. It will continue to serve as a classroom for large lectures.

    Looking toward future phases

    As Butler has seen a 50% enrollment increase in the past decade, Burton-Krieger said the science departments will be at capacity upon completion of the science complex expansion and renovation. The college of liberal arts and sciences is the largest college on campus, with over 35 programs.

    Burton-Krieger said Butler has done two things intentionally in the construction process: allocated potential expansion room on the roof for a fourth floor, and left room at the back of the current expansion.

    The complex will have a campus-wide impact, since all Butler students are required to take a Natural World class with a lab element as part of the core curriculum.

    Not only does it impact our science majors and our COPHS majors, but also with the core requirement, every student will benefit from this building, which is one of the very few places on campus that actually happens, Burton-Krieger said. So this is a project that is for all Butler students.

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    Behind the scenes of Butler's science complex construction - The Butler Collegian

    Why now is the perfect time to renovate your homeand add to its value – Toronto Life

    - October 20, 2020 by Mr HomeBuilder

    With a home equity loan from Alpine Credits, you can upgrade your living conditions and increase your homes value

    As the current global situation keeps us physically distanced from each other and the world outside, were focusing more on the safety and comfort of home life. Since we dont know how long the current situation may last, some of us are looking to make our homes as comfortable as possible.

    Many homes have an underutilized space, whether its a spare room, large attic, or unfinished basement, and theres never been a better time to renovate that space and put it to use. A renovation wont just make your living conditions more enjoyable, itll also add value to your home.

    Of course, home renovations cost more than most of us have sitting around. One way to finance your renovation is by leveraging your homes equity. Your home can be your best collateral: lenders view borrowing against it as low-risk, which means youre likely to get lower ratesand make smaller monthly interest payments as a result.

    There are other ways to save money during a home renovation too, such as taking advantage of home renovation tax credits. We asked Alpine Creditsa pioneer in the private lending marketto help us examine the costs of finishing a basement and advise us on the best ways to finance it. Heres what they told us:

    The costs of finishing a basement

    Basement renovations are among the most common types home modifications in Canada. Finishing your basement can cost, on average, between $35 and $55 per square foot, depending on your planned usage. Obviously, turning a basement into a standalone living area with its own bathroom and kitchen will cost more than building a simple rec room or office space. A full basement renovation can cost between $22,000 and $82,000, depending on the size (square feet), while renovating your basement for use as a recreational or home office space is more in the $14,000 to $50,000 range.

    The benefits of finishing your basement

    Whatever way you decide to go, finishing your basement is one of the best investments you can make in your home. For one, it raises your propertys value, making it more attractive to a future buyer who wont have to worry about doing the work themselves. Finishing your basement can also be a way to bring in a bit of extra incomeup to tens of thousands of dollars a year!by creating a standalone rental apartment.

    Financing your renovation

    Even a simple home renovation can cost more than most people have on hand. One of the best ways to finance it is with a home equity loan. Home equity loansare among the most popular means of financing home renovations. They work by providing access to the equity youve built up in your home over the years. This equity can easily be enough to cover the cost of your renovation.

    Why use a home equity loan rather than putting the cost on a credit card or line or credit? For one, interest rates on a home equity loan usually are much lower. And taking out a home equity loan with a lender like Alpine Credits, instead of a traditional bank, can save you even more money. Plus, lenders like Alpine Credits dont take your credit score into accountthe main criteria is that your home has enough equity to cover the cost of the loan.

    Tax credits

    Unlike most home renovation tax credits, a home equity loan from Alpine Credits doesnt come with a list of eligible and ineligible renovations. The equity youve built up in your home is yours, and you can use it as you see fit.

    A home renovation is just one of the many ways a home equity loan can help change your lifeand Alpine Credits is here to support you along the way. For more than 50 years, Alpine Credits has helped Canadian homeowners get the home equity loans they need, when they need it, regardless of their credit, age or income.

    Contact Alpine Credits today to make your financial dream a reality.

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    Why now is the perfect time to renovate your homeand add to its value - Toronto Life

    12-Year-Old Helps DIY Mom With Home Renovations During COVID-19 – My Modern Met

    - October 20, 2020 by Mr HomeBuilder

    The initial COVID-19 lockdowns were easier said than done. Staying home sounds great in theory, but what is a kid to do when theyve exhausted the activities around their house? For a 12-year-old named Bea, that meant sprucing up parts of her familys abode in Kent, UK. With her DIY-expert mom Susie Levache as a guide, Bea helped transform areas of the home into chic spaces on a budget. Over the course of a week, they spent just about $125 to renovate parts of the house by largely repurposing items and using supplies they had on hand.

    Some of Beas additions include wood paneling placed in her moms office and making upgrades to hardware on cabinets. Susie taught her to use tools like a handsaw, electric drill, and tile cutter, giving Bea the confidence to take on her own DIY tasks while helping her mom, too. Ive pretty much been trucking through our house renovation solo, Susie tells My Modern Met, so when I had help and Bea took a very active role in the room updates, it was wonderful to go from solo to a team!

    Despite teaching her some serious power tools (that many adults would be apprehensive to use), the most challenging lesson that Susie has taught her daughter is all in her head. The most difficult thing was to get her to believe in herself and let her know there was no jeopardy and that if something went wrong we could fix it together, she says. Once this was overcome there wasnt any work or project that she didnt want to tackle.

    Bea is already developing her own decorating voice. Her style and the way she goes about the physical work is far more precise and clean than mine, Susie explains. Im very slapdash and do things impulsivelyshe thinks and plans because she wants to get things right the first time. She will also start with a color and build from that whereas I want to see the whole picture.

    Working together and chronicling it on Susies Instagram has gained admirers throughout the world. Weve been over the moon at the responses and the messages we have received from as far and wide as China and Australia with photos of other peoples first-time projects, and we hope to add more how-to videos on our Instagram in the next school holiday.

    Susie Levache: Instagram

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    12-Year-Old Helps DIY Mom With Home Renovations During COVID-19 - My Modern Met

    Qanvast Providing Peace of Mind on Home Renovation During Uncertain Times – Yahoo Finance

    - October 20, 2020 by Mr HomeBuilder

    TipRanks

    Its the final countdown. With the U.S. Presidential election only two weeks away, election year stress is making the rounds on Wall Street, but one pro argues that regardless of the outcome, opportunity could emerge.Oppenheimers Chief Investment Strategist John Stoltzfus notes that in the last leg of the race to the White House, the markets appear to be signaling that no matter how loud the rhetoric gets from either side and no matter which side wins, investment opportunity in some form is likely to prevail over risk beyond inauguration day in January 2021. He added, In our experience opportunity often arises from uncertainty while a perception of certainty often breeds complacency.As for Q3 earnings season, its already surprising to the upside. Although its still too early to tell how the season will play out, Stoltzfus says so far so good. Data from the past weekend shows 84% of companies that already reported have beat earnings expectations and 82% have exceeded revenue expectations for the quarter. Taking Stoltzfus outlook into consideration, Oppenheimers analysts are pounding the table on two under-the-radar stocks, noting that each could double or more in the next year. Using TipRanks database, we found out that the rest of the Street is also on board, as each boasts a Strong Buy consensus rating.NeuBase Therapeutics (NBSE)Developing the next generation of gene-silencing therapies with its flexible, highly specific synthetic antisense oligonucleotides, NeuBase Therapeutics wants to improve the lives of patients everywhere. Based on the strength of its platform, Oppenheimer thinks big things could be in store.Firm analyst Hartaj Singh highlights the company'sPeptide-nucleic acid (PNA) AnTisense OLigonucleotide (PATrOL) platform, which enables rapid drug design to treat various medical abnormalities, systemic delivery (IV), blood-brain barrier penetration, increased cell permeability, access to genomic loci and secondary RNA structures and the development of highly selective therapies, as overcoming the technical limitations to first-generation antisense oligonucleotides (ASOs).We believe that in the profound potential of ASOs to treat diseases, the current field of first-gen therapies has created a hurdle for a company like NBSE, whereby its technical advantages to ASOs through its PATrOL platform could lead to therapies with a better risk/benefit profile, Singh explained.Additionally, the long-tail redistribution of NBSE's PNAs could have significant implications in terms of the dosing regimens for these agents (potentially weeks to months). Singh mentioned, In combination with the enhanced druggability of targets via PNAs, we continue to view the PATrOL platform's potential highly, with the customary attention reserved for safety on such novel medicines.After the first half of 2020 helped shine additional validation on this platform, the company remains on track with its lead Huntington's disease (HD) candidate, NT0100. Additional preclinical results and candidate selection are set to come by YE20.Looking at the available preclinical NHP data, it supports broad biodistribution and rapid tissue uptake following systemic (IV) administration, an important feature of the platform, according to Singh. As the delivery of therapeutics and their penetration of deep brain structures remain of paramount importance for diseases such as HD, we are encouraged leading up to additional PD data from preclinical models (Q4 2020) Despite the early nature of these preclinical NHP PK data and in-vitro PD data, we believe that they strongly validate the approach NeuBase has taken to truly develop a better mousetrap, and differentiate its technology from conventional ASOs, he commented.These features are inheritable across the class of PNAs NeuBase hopes to bring forward, and thus, Singh has high hopes for NT0200, its product for HD and myotonic dystrophy (DM1). DM1 is trailing the HD program by approximately six months. Following candidate selection in 1H21, IND-enabling studies could kick off. Everything that NBSE has going for it prompted Singh to leave his Outperform (i.e. Buy) rating as is. Along with the call, he keeps the price target at $17, suggesting 104% upside potential. (To watch Singhs track record, click here)Are other analysts in agreement? They are. Only Buy ratings, 4 to be exact, have been issued in the last three months. Therefore, the message is clear: NBSE is a Strong Buy. Given the $16.50 average price target, shares could soar 97% in the next year. (See NBSE stock analysis on TipRanks)Prevail Therapeutics (PRVL)Next up we have Prevail Therapeutics, which is developing disease-modifying gene therapies for patients with Parkinsons disease and other neurodegenerative disorders. After an impressive update on the progress of its pipeline, Oppenheimer likes what its seeing.Representing the firm, analyst Jay Olson highlights the encouraging data from the Phase 1/2a PROPEL trial evaluating its lead candidate, PR001, in Parkinsons disease (PD) patients with the GBA1 mutation (PD-GBA). This mutation affects roughly 9% of all PD patients in the U.S.Looking more closely at the trial, it enrolled two patients, with preliminary data demonstrating normalization of CSF GCase activity at month-three from undetectable levels at baseline. According to Olson, this strongly suggests clinical improvement. It should be noted that there were serious adverse events (SAEs) at month-three, likely related to immune response to AAV9 capsid, that resolved. However, the analyst argues the immune response in AAV9 gene therapies is normal and transient.Additionally, PRVL submitted a protocol amendment for the PROPEL trial, and enrollment is expected to continue in 2H20. The company wants to change the design to an open-label study targeting 12 patients, including the two current patients, and plans to optimize the immunosuppresive regimen to spare steroid administration. To this end, two-month safety and biomarker data in a subset of patients is set to come by mid-2021. Should the therapy ultimately be approved for this indication, Olson sees possible 2035 risk-unadjusted sales of $8 billion.On top of this, a normalization of CSF GCase activity at month-four from undetectable levels at baseline was also seen in a Gaucher disease (GD2) patient on PR001 within compassionate use program. This rare inherited lysosomal disorder is also caused by autosomal recessive inheritance in the GBA1 gene.In Olsons opinion, this result provided positive read across to the Phase 1/2 PROVIDE study in GD2, initiating in 2H20. Because GD2 is an ultrarare disease that affects infants and results in a very short life expectancy, we believe the GD2 indication has a shorter regulatory pathway compared to other GBA1-related indications. We estimate PR001 approval, if clinically successful, may happen in 2024 given a lack of treatments for GD2 patients, he mentioned. Whats more, the Phase 1/2 PROCLAIM study of PR006, its therapy for GRN frontotemporal dementia (GRN-FTD), is expected to kick off in 2H20, with the two-month biomarker readout from a subset of patients slated for late 2020 or early 2021.Given all of the above, Olson stated, We view share price at an attractive entry point while PRVL remains well-capitalized with $131 million in cash providing runway into 1H22.It should come as no surprise, then, that Olson stays with the bulls. In addition to an Outperform (i.e. Buy) rating, he left a $25 price target on the stock. Investors could be pocketing a gain of 156%, should this target be met in the twelve months ahead. (To watch Olsons track record, click here)All in all, other analysts echo Olsons sentiment. 5 Buys and no Holds or Sells add up to a Strong Buy consensus rating. With an average price target of $23.25, the upside potential comes in at 139%. (See PRVL stock analysis on TipRanks)To find good ideas for stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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    Qanvast Providing Peace of Mind on Home Renovation During Uncertain Times - Yahoo Finance

    ADT and the Scott Brothers to Provide Home Makeover to Deserving Family – GlobeNewswire

    - October 20, 2020 by Mr HomeBuilder

    BOCA RATON, Fla., Oct. 19, 2020 (GLOBE NEWSWIRE) -- ADT (NYSE: ADT), a leading provider of security, automation, and smart home solutions serving consumer and business customers in the United States, has partnered with twin TV hosts and designers Drew and Jonathan Scott, to deliver a home makeover to a deserving family. Today, ADT announced that the Moffitt family of Southern California will receive a $250,000 home makeover from ADT, designed by the Scott brothers, along with a professionally installed ADT smart home security system.

    The Moffitts entered the ADT Pass the Protection contest that asked families to share what they wanted to protect and why for the chance to win a home makeover and ADT smart home security system. Grand-prize winners Jeff and Amber Moffitt are parents to six children, including three adopted children, two of whom have special needs and require round-the-clock care. The challenges of raising six children amid the ongoing pandemic were made more difficult when the Moffitts were forced to evacuate their home earlier this year, on account of the earthquakes that struck Southern California. After sharing their incredible story in their entry, ADT and the Scott Brothers partnered to assist them in a redesign of their home, which will include expanding their kitchen to fully accommodate their family and converting their garage into a therapy space.

    Along with the home renovation, the Moffitts will receive a professionally installed ADT Command & Control smart home security system that includes indoor and outdoor cameras, smoke and carbon monoxide detectors, a video doorbell, and smart lock. The smart home functions and ADT Control app will help provide the Moffitts with greater security and peace of mind. The family will also receive three years of ADT professional monitoring and home automation services.

    Jeff and Amber are such a wonderful and selfless couple, and working with ADT to surprise this deserving family has been incredible, Drew Scott said. Collaborating with the entire family to help design a house that will give them much-needed extra space, including a therapy room, makes this project extra-special, Jonathan Scott added.

    Drew and Jonathan surprised the family via a virtual video reveal and visited their home in-person to do a walkthrough and finalize the renovation plans.

    We are beyond excited to be selected as the winners and the kids are over the moon - especially about the therapy room, Jeff Moffitt said. We cant thank ADT and Drew and Jonathan Scott enough for giving us the house of our dreams when we needed it most, Amber Moffitt added.

    The Moffitts story is one of resilience and compassion and good news when we need it most, said Shannon Hendrickson, Vice President of Marketing at ADT. We are delighted that ADT could partner with the Scott Brothers to give the Moffitt family a home makeover and an ADT smart home security system to help their family stay healthy and secure in a space that meets their needs.

    To follow the Moffitts renovation journey, go to https://www.adt.com/passtheprotection.

    About ADTADT is a leading provider of security, automation, and smart home solutions serving consumer and business customers through more than 300 locations, 9 owned and operated monitoring centers, and the largest network of security professionals in the United States. The company offers many ways to help protect customers by delivering lifestyle-driven solutions via professionally installed, do-it-yourself, mobile, and digital-based offerings for residential, small business, and larger commercial customers. For more information, please visit http://www.adt.com or follow us on Twitter, LinkedIn, Facebook, and Instagram.

    ADT Media RelationsPaul Wiseman561-356-6388paulwiseman@adt.com

    See original here:
    ADT and the Scott Brothers to Provide Home Makeover to Deserving Family - GlobeNewswire

    We’ve mapped out the 22 homes that were destroyed or damaged by the Cal-Wood fire – The Colorado Sun

    - October 20, 2020 by Mr HomeBuilder

    The Cal-Wood fire in Boulder County destroyed at least 20 homes on Saturday and damaged two more.

    County officials on Sunday released the addresses of the homes that were destroyed and damaged. Weve mapped them below so you can better understand the fires toll.

    MORE: She thought the evacuation was a precaution. Then the Cal-Wood fire erased her familys Boulder County home.

    Nearly 9,000 acres burned and thousands of people were forced to flee their homes as the fire raced down Lefthand Canyon from near the Cal-Wood Education Center near Jamestown on Saturday afternoon.

    In addition to the houses and two undeveloped lots destroyed in neighborhoods north of Lefthand Canyon Road, two privately owned structures burned near Heil Valley Ranch, a Boulder County Open Space property popular with mountain bikers.

    The Cal-Wood fire is the largest by acreage recorded in Boulder County history.

    Heres a look at the burn area:

    Support local journalism around the state.Become a member of The Colorado Sun today!

    See the original post:
    We've mapped out the 22 homes that were destroyed or damaged by the Cal-Wood fire - The Colorado Sun

    Restoration Australia: an easy watch about heritage glow-ups or another coat of whitewash? – The Guardian

    - October 20, 2020 by Mr HomeBuilder

    Like a kind of Grand Designs with more trips to the library, Restoration Australia has returned for another season of genteel Victorian houses, crumbling cottages and rambling pastoral homesteads, and the brave (or foolish) homeowners working to rescue them.

    Hosted by architect Stuart Harrison, its easily watchable, occasionally delightful television. We root for the country husband-and-wife teams who roll up their sleeves to give old beauties some TLC. We cringe when hubris or inexperience leads to baffling misses, like last seasons stainless steel mesh cocoon. We revel in millennial renter schadenfreude when unexpected structural issues start to bleed money, and nod knowingly at a well-restored wrought iron veranda (having learnt about the intricacies of Italianate motifs moments earlier).

    But the limitations of its historical inquiry can sometimes prove frustrating. Series three began earlier this month in fraught territory: Milton Terrace, an 1879 townhouse in the shadow of the Sydney Harbour Bridge bought for $4.2m in 2015 as part of the Baird governments controversial sell-off of harbourside public housing. We now watch its new property developer owners spend millions more turning several spartan, subdivided government housing flats into one four-storey slice of Mayfair-inspired global glam.

    The protests that greeted the sale and evictions are briefly addressed by the show, but like in The Blocks 2018 overhaul of St Kildas Gatwick hotel, the grim subtexts of gentrification and inequality are largely sidestepped. Offsite, Harrison meets with historians and heritage experts who fill us in on the buildings past, from the merchant whose original 1820s residence was subsumed into the Victorian-era terrace, to the 1900 plague outbreak that first prompted the government to take ownership.

    But what about the stories we dont hear? We are invited to marvel at the giant sandstone blocks of Milton Terraces ground-floor kitchen an iconic feature of colonial Sydney architecture but are stopped short of reflecting on the transformative effect such quarrying, building and occupation had on the land and life of the Gadigal nation. How Sydney Harbour, ground zero of British colonisation, was once dotted with giant shell middens that were ground up and fired to create the lime mortar holding many of those sandstone building blocks together. Its bitterly poignant to consider the heritage that was torn up and built over to create the two centuries of colonial heritage now protected by reams of planning restrictions and passionate community advocacy.

    Last Sundays episode descends on an 1876 home in Inverell, New South Wales: a postcard-pretty country town full of handsome old buildings that mirror the economic windfalls of 19th and 20th century mining and agriculture booms. But would it also be worth noting that it sits half an hour down the road from the site of the Myall Creek Massacre? Its a footnote that adds an important, if painful context: the mineral and pastoral wealth that gave rise to the towns charming architecture were made possible by violent dispossession just a few decades earlier.

    The program has showed it is capable of tackling these issues at least to an extent. In season two, a secluded Tasmanian property dubbed Hunting Ground is found to have been named for the mobs of kangaroos that once thrived there. As a curator at the Tasmanian Museum and Art Gallery tells viewers, such abundance which had been embraced by settlers seeking food was no accident, but the result of years of fire stick-burning by the valleys First Nations people. We dont find out what became of them.

    There is also another, broader undercurrent to the celebration of built heritage: in this country, it has long been used as a symbol of civilisation and tool of colonisation, with the supposed absence of permanent structures pre-settlement held up as evidence of terra nullius. Of course, its now accepted that this is a convenient and Eurocentric myth, laying the groundwork for what Bruce Pascoe describes as colonial amnesia. And there are certainly efforts to explore and revive Aboriginal architecture today a contemporary recreation of historical winter dwellings from south-east Australia by Wiradjuri architect Samantha Rich and Kaurna artist James Tylor is currently showing as part of Canberras public art biennial Contour 556 and DESIGN festival.

    Throughout the series, Harrison and the shows subjects reflect on the idea that these restorations arent just a private act of improving ones real estate investment, but a kind of public service and contribution to their community. I would tend to agree but set against the sidelining of Juukan Gorge and the Djab Wurrung Embassy (to name just two well-known examples), one cant help but be reminded that even in 2020 there remains a disconnect in this country over the kinds of heritage we value and protect.

    Such a reckoning is a lot to ask of Sunday night light entertainment, and questions of sovereignty might be straight up incompatible with any show tied up in Australias 21st century real estate culture. But by stopping short of this bigger picture, theres a risk that its more than just the walls scoring a fresh coat of whitewash.

    See more here:
    Restoration Australia: an easy watch about heritage glow-ups or another coat of whitewash? - The Guardian

    Couple Finds Century-Old Bootleg Whiskey in Walls During Home Renovation – The Dad

    - October 20, 2020 by Mr HomeBuilder

    (Twitch/TheDadGaming)

    Welcome to the club.

    Its the first message that greets you upon visiting The Dad, a nod of acknowledgment that may seem like little more than a cool tagline that is, until you realize what being a member of the club actually means. Being a dad is an experience like no other. Its beautiful and stressful and exciting and exhausting all at once. It comes with challenges that only other dads can understand. Being a member of the club means being surrounded by people like you, and people very unlike you but with one important thing in common: fatherhood. It doesnt take long to realize just how deeply members of The Dad community care for each other, and that level of support extends far beyond things strictly related to fatherhood. When a member of our community celebrates, we all celebrate. If one of us needs help, the response is so enormous its almost deafening. And when we experience a tragedy, we mourn together.

    On October 7, one of our own tragically passed away. RJ Barry was a father, gamer, and a valuable member of The Dad Gamings Rocket League community. RJ loved playing Rocket League and Call of Duty, racing 4 wheelers, skateboarding, but most importantly, the 29-year-old loved his friends and family. Particularly, his daughter Vivian.

    The loss of RJ hit The Dads gaming community hard RJ had been an active member of The Dads Rocket League group since February, participating in weekly Tuesday game nights and befriending dads around the world. RJ was a skilled gamer, regularly making the playoffs and winning tournaments. But more importantly, RJ was a great friend and an amazing dad.

    Jon Melo was just one dad who RJ befriended through The Dads Rocket League group, as the two dads played regularly on the same team (and somehow, lost regularly on the same team). Of course, the one week the two separated, both made the semi-finals before RJs team went on to win the tournament. We always said were going to win it together, Melo recalled.

    Honestly I cant say enough about him, Melo said. He just was such an easy-going person and always there to listen to you if you needed someone. A lot of dads on here would say he was one loving outgoing fun guy to play with and was always positive.

    But for gamer friends and non-gamer friends of RJ, there was one constant: That man loves his daughter and he would do anything for her, Melo concluded.

    The loss of RJ left gamer dads near and far both shocked and saddened. But with the enormous grief that came with the RJs passing came something beautiful a community coming together to mourn and celebrate the life of a friend.

    A post shared by Garrett Van Ginkel, The Dad Gaming Rocket Leagues admin highlighted the true nature of what it means to be a member of The Club. Its about far more than gaming and memes its about having a place to celebrate lifes wins and grieve lifes losses, and never having to do either alone.

    Garretts touching post explained how after RJs passing, members of the community came together to honor their fallen teammate. Together, the group came up with ideas to honor RJ, who played by the name Tartarus. We will be holding a 1 minute moment of silence at kick off of the first round of play, Garrett explained.

    During the moment of silence, each team of 3 loaded in with only 2 players to symbolize that we were all missing a player, Garrett told The Dad.

    And silently, beautifully, the incomplete teams paid their respects.

    We are permanently retiring Team 21, Garrett continued. It was a common team for him to be on due to his rank, and it was the last team he played for in our tournaments. Moving forward, it will be known as Team Tartarus.

    Watch the moment of silence:

    The group even moved their efforts outside the confines of the internet. Garrett explained, I have set up a PayPal account to take donations for his daughter Vivian and his family. We will be promoting it on stream during the tournament, and have it displayed on the overlays so anyone that tunes in will see it. Once all donations are in, I will personally write a check to his family for the full amount in the PayPal account. The email address to donate is: [emailprotected]

    As dads, we want nothing more than to be there for our kids, to take care of them. In RJs memory, the group is collecting money which will go to a trust in Vivians name. Though the trust will provide financial assistance to Vivian one day, it represents so much more than money its emblematic of the true nature of being a dad. If theres a problem, you try to fix it. If you cant fix it, you do everything you can to help, and you do it with a whole lot of love.

    RJ will be forever missed by both his friends and family, but he will always be remembered and he will always be a member of The Club.

    Go here to see the original:
    Couple Finds Century-Old Bootleg Whiskey in Walls During Home Renovation - The Dad

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