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From a young age, Columbus native Shalee Darringer found herself drawn to the Crump Theatre.

Every time she passed it, shed look at the building and longed to go inside.

At five years old, Darringer had a dream: When it was time for her to do her senior project in high school, she wanted to involve the Crump in some way.

Now, in Darringers final year at Columbus East High School, that dream has become a reality.

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For her senior project, Darringer is focusing on helping the Crump Theatre and, as she put it, promoting "healthier lives in our community." As part of these efforts, shes organized a volunteer clean-up day for the Crump this Saturday, with two shifts: 10 a.m. to 12:30 p.m. and 12:30 p.m. to 3 p.m. Each shift has a maximum capacity of 80 people.

With the condition that the inside of the Crump is in right now, the only way that were going to be able to open that up or, like, actually begin the entire restoration process is if we go in there and clean everything out," she said.

In addition to the fire and safety hazards that have kept the building from reopening, Darringer said that the Crump has water damage, mold and mildew.

Theres been a crew thats been working on this for almost a year now, and theyve gotten a lot done personally, but I feel like the more people we have come in, the more well get done," she said.

To help get rid of the damage, some of the workers called the "demo crew" on Darringers sign-up page will be tearing out carpet, removing attached materials and getting rid of anything that can hold water. A hauling crew will then carry all "unnecessary items" outside.

Darringer said that both the demo and hauling crews will be provided with N-95 masks and gloves for their own safety. She stated that the building will be aired out before the first shift begins, and workers will be placed near doors on the first floor, away from any of the "extremely harmful spots."

She added that there will only be a relatively small number of people working inside the building; the majority of volunteers will be outside in order to socially distance.

The exterior maintenance crew will pull vines off the building and clean its front, and the outside cleaning crew will clean materials that are needed for fundraising.

Thats another part of Darringers senior project she plans to auction off items from the Crump to raise funds to buy protective gear for future cleanup efforts. She said this includes gloves and N-95 masks.

Darringer said that she and her project mentor, Jess Schnepp, are setting up an online auction on items from the Crump, including audio tubes and old marquis letters.

Theyre also planning another volunteer event in October to take down the "Love Letters to the Crump" curtains that hang on the buildings exterior wall as part of a 2019 Exhibit Columbus installation. Darringer said that the curtains will be repurposed into reusable shopping bags and sold or auctioned to raise more funds for protective gear.

Shes very passionate about the theatre," said Schnepp. "And she has been working her tail off."

Schnepp is also the community development coordinator for the Bartholomew Consolidated School Corp., an admin on the "Save the Crump Theatre" Facebook group, and project coordinator for the "the Crump Project," separate from Darringers senior project.

We are in phase one, which is prevent and protect, and thats making emergency repairs that might need done to the building, while also accessing the building to see if theres any other repairs that need to be done," Schnepp said. She added that the work also includes working with volunteers to clean up the building and getting quotes from contractors on repairs.

Darringer said Schnepp was the one who told her that helping the Crump as part of her senior project was actually doable.

"Up until last year, that [the Crump] was my only reason I had not wanted to leave Columbus," Darringer said. As a senior, Darringer is looking into different colleges and doesnt necessarily plan to stay close to home.

But before leaving, she wanted to see the Crump get some much-needed love.

"I want to see something actually being done with that, and the way to make me feel better about that is to be part of doing so," she said.

Darringer and Schnepp started making plans for her senior project last November, just after the Crumps 130th "birthday." The celebration was the first time Darringer ever entered the Crump, after years of looking in from the outside and dreaming, from the age of five, about helping the theatre.

For Schnepp, five years old is also a milestone age its when she saw her first movie, "The Dark Crystal," at the Crump. She said the experience left a "lasting impression" on her.

Its that kind of memory that students hope to create by helping revive the Crump, Schnepp said. Darringer isnt the only one whos come to her about the theatre; another senior is planning his project around the theatre as well. In fact, Schnepp said that "students of all ages" have reached out to her about the Crump.

Some of them attribute their interest to the effects of isolation amid the pandemic.

After being quarantined because of COVID and having to do everything virtual, they really want to start having real-life experiences," Schnepp said. "They want to come see a concert. They want to go see a movie. You know, they want to go see a play or a comedian. They want to go do things. And so I think maybe thats part of the draw, is the possibility of a future where they have some place to go and do things.

If you go

To sign up for the Crump clean-up, volunteers can go to the "Clean Up the Crump" event page on Facebook and click on the link under the "Tickets" section, which will take them to a sign-up page for volunteer shifts.

There are two clean-up shifts: 10 a.m. to 12:30 p.m. and 12:30-3 p.m. Each shift has a max capacity of 80 people. Volunteers can sign up for the following jobs:

The majority of volunteers will be working outside, so as to maintain social distancing. Those working inside will be spaced out.

Volunteers should wear close-toed shoes and clothes they dont mind getting dirty. The inside workers will be given N-95 masks and gloves to protect from mold and mildew.

Darringer said that theyre asking for the demo crew to bring carpet knives and other tools to help with their work. The cleaning crew is asked to bring glass cleaner and paper towels. The exterior crew is asked to bring tools to help with either landscaping or work on the marquis.

Where to learn more

More updates on Darringers senior project and Crump clean-up efforts are available at The Crump Theatre page on Facebook and the "Save the Crump Theatre" Facebook group.

Schnepp said that anyone with questions can email her at thecrumptheatre@gmail.com.

Shalee said that they are also partnering with BCSF to raise funds. With a minimum donation of $50 to the school foundation, individuals will receive Columbus Book which contains a "great picture of the Crump." Half of the proceeds will go to the project; the other half will go to the school foundation. More information is available at http://www.bcsfstars.org.

About senior projects

As part of their graduation requirement, all Bartholomew Consolidated School Corp. students are required to complete a senor project.

According to Columbus Easts website, "The Senior Capstone Experience/Senior Project is a student-selected exploration of a topic which results in a research paper, a project or a product, and a presentation. The Senior Capstone Experience moves students away from departmentalized learning toward a more interdisciplinary approach. This approach is one which allows students to use a variety of skills in the areas of writing, speaking, research, and documentation. Upon completion of the Senior Capstone Experience, students have learned more about their topics, their community, and, most importantly, about themselves."

Originally posted here:
Stage and screen and everything clean: East senior organizes Saturday Crump clean-up - The Republic

Courtroom battles. Victories and appeals. Allegations of a judicial conspiracy.

Political parties are involved in a flurry of Ohio lawsuits surrounding the 2020 General Election before the first votes here have been cast.

The Ohio Democratic Party and other voter advocacy groups have filed lawsuits against Secretary of State Frank LaRose seeking to change certain aspects of how the election will be conducted.

Republican interests including the Trump reelection campaign have filed to intervene in each case, arguing any changes enacted could lead to a competitive disadvantage.

Here is an explainer of what the cases are about, and how the results may affect Ohio voters this election season:

Drop BoxesThere are two pending lawsuits related to the use of ballot drop boxes.

Background:Ohioans who request an absentee ballot have two available methods of returning it. They can mail it back to their countys board of elections office, or they can drop it off in a secure drop box located at that office.

Secretary LaRose issued a directiveto all 88 counties that they are to make one drop box available for the fall election. Ohio Democrats and voter rights groups want more drop boxes made available in other areas of Ohio, not just one located in each county seat.

The suits: Ohio Democrats sued LaRose in Franklin County Common Pleas Court with the hopes that a judge would deem LaRoses directive invalid thus letting county boards of elections install more drop boxes if they so choose.

In court, LaRoses lawyers argued that Ohio already provides numerous ways for people to vote safely and conveniently, with no further change necessary. The Democratic Partys lawyers argued that no existing state law prohibits the installation of more drop boxes.

The Democrats believe drop boxes are a useful tool for voting this fall, as both a way to avoid casting a ballot in person amid the pandemic and also to avoid any postal delays.

The Trump presidential campaign, the Ohio Republican Party, the Republican National Committee and the National Republican Congressional Committee all jointly filed to intervene as party defendants. In essence, this means they appeared in court to argue against the plaintiffs case.

Collectively, they argued that changing the number of drop boxes in each county could alter the competitive environment for the 2020 election.

There is a second lawsuit related to drop boxes filed in federal court. The League of Women Voters and several other advocacy groups are also suing LaRose over the drop box issue. Republicans have intervened in the case. A hearing is scheduled for Sept. 23.

Result of lawsuits:In Franklin County, Judge Richard Frye ruled that existing state law does not support LaRoses one-drop box-per-county directive. Frye ruled it would be lawful for counties to install more drop boxes as they see fit.

After some legal back-and-forth, Frye wound up issuing an injunction to prevent enforcement of the drop box directive. LaRose has appealed the ruling, and the injunction is halted until the appeal can be heard.

After the ruling was announced, the Ohio Republican Party issued multiple tweets and statements accusing Frye, a Democrat, of having colluded with the plaintiffs during the case.

Those Republican statements received immediate backlash,including a lengthy condemnationfrom Ohio Supreme Court Chief Justice Maureen OConnor, a Republican.

Every one of Ohios 722 judges, 800 magistrates, and numerous active-retired judges should be greatly concerned and voice their dismay at the irresponsible Republican Party allegation that politics controlled the judges decision, OConnor wrote. This is a blatant and unfounded attack on the independence of the Ohio judiciary.

The tweets were later deleted. A lawyer for the Ohio Republicans told Frye the legal counsel was not involved with issuing the accusatory statements.

How do these cases affect voters?This legal result may be the difference between having a longer trip to the drop box or a quicker one.

If LaRose prevails, there will still be one drop box available in each county. If not, some county boards of elections may choose to quickly install other boxes before early voting begins Oct. 6.

Online absentee ballot requestsBackground:In Ohio, eligible voters must request an absentee ballot before receiving one.

LaRose issued a directive to the 88 counties that they should only accept absentee request forms that are dropped off or mailed to the board of elections office.

Ohio lawstates an absentee ballot application need not be in any particular form, but must contain specific pieces of voter information such as an address and date of birth.

Voting rights advocates want to see this system modernized to allow for online ballot requests, as it already does for military and overseas voters. (Ohio also currently allows for online voter registration.)

LaRose has said he supports this change, but believes it must come from a new law passed by the state legislature. State Sen. Theresa Gavarone, R-Bowling Green,introduced legislationto this effect in 2019 but it has not gained much traction.

The Ohio Democratic Party sued LaRose in Franklin County Common Pleas Court, with the phrase need not be in any particular form at the center of its lawsuit. The suit hoped to have a judge declare that boards of elections could accept absentee ballot requests from all voters by digital means.Once again, Republicans and the Trump campaign intervened and argued such a change could alter the elections competitive environment.

Result of lawsuit:On Sept. 11, Common Pleas Judge Stephen McIntosh ruled in favor of the Democrats. McIntosh issued an injunction to prevent enforcement of LaRoses directive.

LaRoses office quickly appealed the ruling to the 10th District Court of Appeals in Ohio. The injunction is halted so that the appeal can be heard.

LaRose said in a statement that McIntoshs ruling would make Ohio vulnerable to cyberattacks. He takes issue with elections officials having to potentially download emailed attachments of completed ballot applications.

Todays ruling rolls out the red carpet to Russian hackers painting a giant bullseye on the back of our election system and upending the significant progress Ohio has made on elections cyber security, he said.

The appeal is pending.

How does this case affect voters?The ruling would impact the way in which voters would be able to request absentee ballots over the next six weeks.Election Day is Nov. 3; an absentee ballot request must be received by an elections office at noon on Saturday, Oct. 31 in order for it to be processed.

Should the lower courts ruling hold up, voters would be able to send in the request digitally rather than through the mail.

Regardless of form, LaRose has urged Ohioans to not wait until that final available day to submit the ballot request he warned it may be impossible for a ballot to be mailed out to a voter and returned in time to be counted.

An absentee ballot must be postmarked by Nov. 2, the day before the election, in order to count. Or it can be dropped off at a ballot drop box up until polls close at 7:30 p.m. on Election Day.

Signature matchingBackground:In Ohio, voters have to sign their absentee ballots and ballot request forms. Elections officials compare these signatures to the one on a voters original registration. If its a match, the ballot is deemed valid. If not, it may be rejected.The Associated Press reportedthat thousands of Ohio absentee requests were denied in 2018 because of missing or mismatched signatures.

The signature check is viewed as a way to verify the correct person is filling out an absentee ballot. Voting advocacy groups believe the system is too subjective and leaves otherwise eligible voters vulnerable to disenfranchisement.

In July, the League of Women Voters of Ohio and the A. Philip Randolph Institute filed a lawsuit against LaRose in U.S. District Court.

The lawsuit seeks that the court declare the signature matching process (as currently practiced) to be unconstitutional. The plaintiffs want to see uniform standards put into place, and hope the court will issue an injunction to prevent county boards of elections from carrying out signature matching checks until such standards are enacted by LaRoses office.

Republicans have intervened in the case.

Result of lawsuit:Judge Michael Watson has yet to decide on the matter of issuing an injunction.

How does this case affect voters?This depends on how the court rules, and in what way absentee voter verification may be altered for future elections.

LaRose has said county boards will work to contact voters directly if there are issues with their ballots, with a cure period in place to get valid ballots properly counted.

Tyler Buchanan is an award-winning journalist who has covered Ohio politics and government for the past decade. A Bellevue native and graduate of Bowling Green State University, he most recently spent 6 1/2 years as a reporter and editor of The Athens Messenger and Vinton-Jackson Courier newspapers. He is a member of the BG News Alumni Society Board and was a 2019 fellow in the Kiplinger Program in Public Affairs Journalism.

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What's going on with all the Ohio elections lawsuits? An explainer - The Highland County Press

Edwardsville American Legion Post 199 is among the organizations that say it can benefit from video gaming.

Edwardsville American Legion Post 199 is among the organizations that say it can benefit from video gaming.

Photo: Intelligencer File Photo

Edwardsville American Legion Post 199 is among the organizations that say it can benefit from video gaming.

Edwardsville American Legion Post 199 is among the organizations that say it can benefit from video gaming.

'It came as a shock': Edwardsville groups react to gaming ban

EDWARDSVILLE When a revised version of an ordinance allowing video gambling was voted on by the Edwardsville City Council on Sept. 25, proponents of the measure felt certain that it would pass.

But they were in for a surprise.

The council voted 3-4 against video gaming, with aldermen Jack Burns, Craig Louer and Art Risavy voting for the amended ordinance, which would have allowed the areas fraternal organizations, the Knights of Columbus, the Loyal Order of the Moose and the American Legion post, along with Class A and Class D liquor license holders to conduct video gaming.

The original video gaming ordinance would have allowed many bars and restaurants and other local businesses to have video gaming.

On Sept. 10, the administrative and community service (ACS) committee unanimously voted to modify the original ordinance.

With a limit on indoor dining and indoor drinking [due to the coronavirus], we have lost a lot of revenue, said Steve Bollman, manager of On the Hill Golf Course and Lounge at Edwardsville American Legion Post 199. Video gaming would be a great source of revenue that historically fraternal organizations have had. We had a couple of people from the city tell us that we had nothing to worry about and we would be getting the machines.

They said that the city cares about the fraternal organizations and the veterans organizations and they wanted to make sure [the video gaming ordinance] goes through to help those organizations, which are struggling at this time. That some of them went back on their word and changed their vote is kind of a sore subject.

Rob Eberhardt, a Post 199 board member and former post commander, is among those who spearheaded the push for video gaming.

Like Bollman, he was surprised not only by the amended ordinance being voted down but by some businesses being excluded.

It came as a shock because we felt we had enough support from the city, Eberhardt said. Running a restaurant is tough enough and running a Legion post is just as tough. Throw the pandemic on top of it and youve got some people who are in critical condition in terms of economics.

When Mayor [Hal] Patton came up with the proposal [for video gaming], it made great sense and he told me he hoped it would help the businesses that were struggling, as well as the service clubs in the area. He did extensive research on the impact that video gaming would have in the area and the new revenue that would be produced is significant.

The rejection of video gaming left some members of fraternal organizations feeling like they had been misled by the city. They feel that the alderman that voted against the ordinance are not representing the views of most residents.

Its not so much what you think its what the people of Edwardsville think, said Jim Acra, governor of Edwardsville Moose Lodge 1561. There was not one person that came to these meetings to oppose this. It was very disappointing because people didnt stand up and vote the way the way they need to vote.

I feel bad about the businesspeople of Edwardsville who are going to miss out on this. Then they turned around and voted so that nobody will be able to have it.

For organizations such as the Moose Lodge, video gaming could have a huge financial impact at a time when it is needed most.

Our gaming people have done games at the Moose Lodge for 30 years and they told us conservatively that if we bring in these machines, it could bring in $10,000 a month, Acra said. The big portion of our money was from renting our hall for parties and fundraisers and we havent had anything like that since March.

We did get a loan, but we also had money in the bank, so were blessed in two ways. But its still a huge challenge for us. If we get this money [from video gaming], we could do things like put down new carpeting in our social quarters, which is the bar area, and we could do some other improvements.

Bollman, likewise, cited a growing need for additional revenue at the American Legion.

We have much-needed maintenance on our building and we need money for scholarships, Eberhardt said. A lot of that money [from video gaming] can go to good things up here, including the citys Fourth of July fireworks display. They had to move it this year, but hopefully, we will get it back.

Were a not-for-profit, so there are no owners that benefit from the money we make here. It all goes back into the place or around the community. It helps us keep the prices low for hall rentals, weddings and fundraisers on the golf course. Events like that are what keep this place open.

For owners of bars and restaurants, the loss of potential revenue from video gaming is equally disappointing.

I didnt go to the first city council meeting [on Sept. 1], but Steve Seibert [co-owner of Big Daddys with Tim Bauer] told me about the second one, said Jason Armbruster, co-owner and operator of the Foundry Public House in Edwardsville. We didnt know a lot about it, but once we got into it, we found that could help so many people out.

Theres a lot of talk about addiction, but we as bar owners deal with that every day. If we have a bad drunk, we kick them out, and if we had bad gamblers, we would get them out too. Thats our responsibility to the public.

Armbruster was especially upset that bars and restaurants were excluded from the video gaming ordinance before it even came to a vote.

It was a weird situation and they tried to give it just to the fraternal organizations and gas stations, which is totally unfair, and even a lot of people in the fraternal organizations said you cant do that, said Armbruster, whose business partner at the Foundry is Rodney Lanham. In a day and a half, we got 370 signatures [supporting video gambling], but no one from the council ever came to my bar and got my opinion about it.

For a lot of people on the council, everything was I this and I that, and it doesnt seem like they are representing the people. It seems like they have their own agenda.

Armbruster said that if video gaming eventually is approved by the city, the Foundry does not intend to have any machines installed. But he supports the rights of other businesses and organizations to have video gaming.

Were fortunate enough that we have a huge patio, so were doing way better than most, even if were down 60 percent on the year, Armbruster said. But places like the Corner Tavern can totally use that revenue stream and the city could use it. Youre talking hundreds of thousands of dollars if everybody gets on board with it.

The earliest that the issue could be put before the voters is the April 6, 2021, consolidated election.

Proponents of video gaming feel they would have the voters support.

Were looking to have this put on the ballot in April, but its unfortunate that it has to do that long, Acra said. At the Moose Lodge, were going to move on and do what we need to do to survive. I know several of our members are going to be adamant about not getting some people reelected to the City Council, and that also comes up in April.

The citys share of the tax revenue would have been directed to water system improvements, business development programs, including faade improvement grants and historic renovation grants that directly benefit businesses.

For now, though, neither the city, nor local businesses and organizations, will be able to generate revenue from video gaming. Edwardsville, Glen Carbon and Maryville all banned video gaming. It is allowed in Madison County.

There are a lot of businesses that wont reopen unless they get something like this, Armbruster said. Its legitimate help and its not a handout. The businesses and the city can gain revenue and the state will get their cut.

Theyre constantly making it sound like were going to have degenerates coming in here and were going to put big neon signs in front of our building saying Slots. Its unfortunate that every other county around us has gaming and Edwardsville doesnt.

Original post:
'It came as a shock': Edwardsville groups react to gaming ban - The Edwardsville Intelligencer

Trunk organizers are game-changers. They can quickly turn a cluttered, mess of an interior into a neatly packaged, nice place to spend time. This is especially true if you have kids, or love to go on long trips. Thinking about picking up an organizer for your car? Here are our favorites.

Drive Auto Collapsible Car Trunk Storage Organizer

Drive Auto's collapsible trunk organizer is the best-selling organizer on Amazon right now, and for good reason. It uses hooks to mount into place, so it doesn't move around while the car is in motion. There's also plenty of side pockets to all sorts of items, including work folders, mugs, phones, tablets, tools, and more.

Honey-Can-Do Folding Car Trunk Organizer

On a budget? This simple organizer from Honey-Can-Do has everything you need to get your trunk sorted out, all while being priced under $15. There are two main cargo areas, a handful of side pouches, and even handles on either end for easy transportation.

Picnic at Ascot Heavy Duty Rigid Base Trunk Organizer

On the higher end of the price spectrum sits Picnic at Ascot's heavy-duty trunk organizer. It's the most expensive item on this list, but its also the biggest, and comes with a removable cooler you can take with you once you arrive at your destination. If you're willing to drop the cash, you won't be disappointed.

FORTEM Car Trunk Organizer With Foldable Cover

If you want to keep your stuff covered or hidden from view, we recommend picking up Fortem's modular trunk organizer for your ride. It also uses hooks to hold itself in place, and comes with a handful of removable dividers, meaning you can modify it for your specific needs.

YoGi Prime Backrest-Mounted Car Trunk Organizer

Unlike your average box-type organizer, which sits on the floor of your back seat area or trunk, YoGi Prime's design is mean to be hung from your car's headrests. This saves space and makes for easy organization and access. Installation is easy, and hiding valuables is simple thanks to the built-in pouch covers.

Knodel Sturdy Car Trunk Organizer With Cooler Bag

Going on a road trip with family, and want to keep your snacks fresh? This organizer by Knodel comes with a built-in insulated cooler section perfect for keeping items at the right temperature for extended periods of time. Available in two- or three-compartment configurations, it's a must-have for long journeys.

Multipurpose Cargo Organizer Blocks

If your trunk consists of larger or heavier items, it might be worth it to pick up a few of these organizer blocks to keep everything in place. Designed to be mounted to the carpet of any wool trunk, they're perfect for keeping big items from sliding around.

High Road CargoCube Trunk and Car Organizer Bins

Want to keep things simple? These two "CargoCubes" from High Road are the perfect things for your trunk. They're basically nicely-dressed boxes with handles, easy for keeping stuff contained. There are front mesh pockets for storing smaller items, and handles for easy movement.

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100 years ago

Sept. 21, 1920: Local businesses are spending almost $3 million on construction and remodeling this year. The Consistory building is still the biggest project at $600,000. Next is the Lafayette Apartments at $300,000. (The Lafayette is only project still serving its original purpose.)

75 years ago

Sept. 21, 1945: From the now it can be told file: The Sylvania plant in Bloomington made contributions to Britains radar program by making tubes the British couldnt. Other tubes were used against Japan in missile nose cones, making the missiles explode as they near their targets.

50 years ago

Sept. 21, 1970: Work crews are setting up a prefabricated portable classroom at Raymond School on the west side. Its a step to ease overcrowding but it wont have toilet facilities. Remedial reading and resource programs will be housed there.

25 years ago

Sept. 21, 1995: Danny Tomlinson of Gibson City was convicted of beating up Saybrook Police Chief Madeline Nickum. She had stopped him on suspicion of DUI. Tomlinson, 44, faces a 10-year sentence and possibly more. The chief is still suffering after-effects of her injuries.

Compiled by Jack Keefe; jkeefe@coldwellhomes.com.

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100 years ago: $3 million in construction, remodeling set - Bloomington Pantagraph

Androgen deprivation therapy (ADT) is a cornerstone treatment for locally advanced or metastatic prostate cancer (PCa). However, its potential effects on the tumor immune microenvironment (TIM) of PCa patients and the underlying mechanism remain largely unclear. To explore the effects of ADT on PCa TIM, RNA sequencing was performed on six paired pre-ADT biopsy and post-ADT PCa lesions, and five paired paracancerous benign tissues from patients receiving neoadjuvant ADT with locally advanced PCa. Bioinformatics methods including ESTIMATE and ssGSEA were used to evaluate the stromal immune score and immune cell infiltration in PCa and paracancerous tissues. Weighted correlation network analysis was used to screen hub genes in the ADT-induced immune remodeling process. The results showed differences exist between PCa and paracancerous tissues in response to ADT. Compared with paracancerous tissues, the immune remodeling effect of ADT in PCa was more intense. ZFP36, JUNB, and SOCS3 served as hub genes in the ADT-induced immune remodeling process and were associated with PSA recurrent-free survival in the TCGA and our neoadjuvant ADT cohort. To investigate the joint action of the above three hub genes, an immune signature score was constructed. The results showed that immune signature score-based immune subtypes reveal the heterogeneity of the immune microenvironment of PCa and showed significant differences in patient prognosis, tumor immune infiltration, mutation burden, and landscape.

Cell death & disease. 2020 Sep 19*** epublish ***

Xingbo Long, Huimin Hou, Xuan Wang, Shengjie Liu, Tongxiang Diao, Shicong Lai, Maolin Hu, Shengqi Zhang, Ming Liu, Hong Zhang

Department of Urology, Beijing Hospital, National Center of Gerontology, No 1, Dongdan Dahua Road, Dongcheng District, Beijing, 100730, China., Graduate School of Chinese Academy of Medical Science and Peking Union Medical College, No. 9, Dongdan Sanjiao Alley, Dongcheng District, Beijing, 100001, China., Department of Urology, Beijing Hospital, National Center of Gerontology, No 1, Dongdan Dahua Road, Dongcheng District, Beijing, 100730, China. ., Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, 100191, China. .

PubMed http://www.ncbi.nlm.nih.gov/pubmed/32951005

Originally posted here:
Immune signature driven by ADT-induced immune microenvironment remodeling in prostate cancer is correlated with recurrence-free survival and immune...

Latest updates on Remodeling market, a comprehensive study enumerating the latest price trends and pivotal drivers rendering a positive impact on the industry landscape. Further, the report is inclusive of the competitive terrain of this vertical in addition to the market share analysis and the contribution of the prominent contenders toward the overall industry.

High intensity of natural calamities particularly in China and Japan display high scope for disaster repair remodeling services. Extreme climatic variations majorly in North America and Europe show strong potential for services related to snow removal and property improvement. Requirement among the aged population to live in a peaceful house environment after their retirement will generate high investments in porch and gardens particularly in developed nations.

Residential remodeling market is expected to witness a CAGR of over 4% during the forecast period 2018 to 2024. Higher count of house gatherings along with rising consumer spending in developing economies will enhance the application market. Technological advancements providing better energy efficiency, enhanced designs, and highly durable materials along with need to increase the house security will drive the business growth globally. Increasing real estate prices in highly populated cities accompanied by the need for improved house space and design will support the services penetration.

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Lower lending rates along with design innovations will primarily drive the global remodeling market growth. Increasing private infrastructural investments along with favorable government conditions offering tax concessions on home loans will enhance the services demand. Expanding tourism sector along with technological innovations particularly in Asia Pacific and Europe will boost the business advancement.

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North America remodeling market revenue was registered over 800 billion in 2017. Design innovations along with large disposable incomes & highest consumer spending are primary drivers for the expanding services demand in the region. Extreme climatic variations accompanied by frequent disasters support the market development in the region. Increasing necessity to improve the employee productivity and reduce energy expenses will propel the services adoption in the commercial segment.

The key industry players in the global remodeling market share include GAF Materials Corporation, JELD-WEN, Andersen Corporation, ABC Supply, Builders First Source, the Home Depot, Dow Building Solutions, Hanley Wood LLC, Ferguson Enterprises, and Fortune Brands Home & Security. Other prominent players in the industry are Lutron Electronics, Kohler Co., Masco Corporation, Move Inc., USG Corporation, National Gypsum Company, Oldcastle Building Products, Owens Corning, Pella Corporation, Ply Gem Industries Inc., ProBuild Inc., The Sherwin-Williams Company, and Mergers & acquisitions are among the key strategies adopted by the service providers to expand their product portfolio and gain market share. For instance, Norcraft companies was acquired by Fortune Brands Home and Security to expand their product portfolio in the residential segment.

Commercial remodeling is expected to account for over USD 2 trillion by 2024. Necessity to reduce the fixed costs particularly electricity expenses along with providing a better environment to work in corporate offices will surge the business expansion. Trend towards transforming the office into eco-friendly to improve employee health, working conditions along with the benefit of social marketing for the company.

Major Highlights from Table of contents are listed below for quick lookup into Remodeling Market report

Chapter 1. Methodology and Scope

Chapter 2. Executive Summary

Chapter 3. Remodeling Industry Insights

Chapter 4. Company Profiles

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Remodeling Market Trends, Companies, Driver, Segmentation, Forecast to 2024 - The Research Process

Brandessece Market Research recently added the Bioabsorbable Stent Market research report which offers a thorough study of the market scenario regarding the market size, share, demand, growth, trends, and forecast from 2020-2026. The report deals with the impact analysis of the COVID-19 pandemic. The COVID-19 pandemic has impacted exports, imports, demand and trends in the industry and is expected to have some economic impact on the market. The report offers a comprehensive analysis of the impact of the pandemic across the industry and provides insights into a post-COVID-19 market scenario.

List of TOP KEY PLAYERS in Bioabsorbable Stent Market Report are Abbott, BIOTRONIK SE & Co. KG, REVA Medical, Inc, Elixir Medical Corporation, Arterial Remodeling Technologies, others.

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Bioabsorbable Stent Industry 2020 Global Market research report studies the latest Bioabsorbable Stent industry aspects market size, share, trends, Opportunities and Strategies To Boost Growth, business overview, revenue, demand, marketplace expanding, technological innovations, recent development, and Bioabsorbable Stent industry scenario during the forecast period (2020-2025).

What are the key segments in the market?

Geographically, the global culture media market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Geographically, North America is expected to hold the largest share of the market, and it is also anticipated to continue this trend in the forecast period. Increased government initiatives for research, the invention of new technologies and advancements in cell culture applications, clinical studies on cancer, the presence of the world-class biotechnology & research institutes in the region are likely to propel the growth of the market in North America. Europe is projected to hold the second-largest share of the market. The growth of the market in this region can be attributed to the enormous investments and research activities in the biotechnology sectors, as well as the increasing trend in the adoption of new technologies. However, the Asia Pacific region is likely to hold the significant potential for the growth of the Bioabsorbable Stent market due to the increase in technological advances in the biotechnology and pharmaceutical sector, development of vaccines, and rising initiatives for in-vitro cultivations. Moreover, the emerging economies like China and India are expected to boost the growth of the market due to the growing capital and purchasing power of the countries in the Asia Pacific region. Latin America and the Middle East & Africa are increasing steadily in the market.

Highlights of the Report:

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Important Facts About Bioabsorbable Stent Market Report:

-The Bioabsorbable Stent industry report features different approaches and procedures endorsed by the market key players to make vital business decisions.-Bioabsorbable Stent market depicts some parameters such as production value, Bioabsorbable Stent marketing strategy analysis, Distributors/Traders and effect factors is also mentioned in this Bioabsorbable Stent research report.-This research report reveals Bioabsorbable Stent business overview, product overview, market share, supply chain analysis, demand and supply ratio and import/export details.

TABLE OF CONTENT

1 Report Overview

2 Global Growth Trends

3 Market Share by Key Players

4 Breakdown Data by Type and Application

5 United States

6 Europe

7 China

8 Japan

9 Southeast Asia

10 India

11 Central & South America

12 International Players Profiles

13 Market Forecast 2020-2025

14 Analysts Viewpoints/Conclusions

15 Appendix

View Full Report @https://brandessenceresearch.com/medical-device/bioabsorbable-stent-market-size-and-share

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Bioabsorbable Stent Market Size Share Analysis and System Production (2020-2026) | Abbott, BIOTRONIK SE & Co. KG, REVA Medical, Inc, Elixir...

Credit: Melissa Turtinen

If someone wants to build or add onto their home in Excelsior, they'll now face a far more rigorous process to get it approved.

A new ordinance the Excelsior City Council passed on a 3-2 vote Monday which goes into effect Oct. 1 gives Excelsior some of the strictest zoning regulations in the state.

Residents in Excelsior, a city with fewer than 3,000 people established in the 1850s on Lake Minnetonka, have been embroiled in a years-long debate over preserving the city's charm or allowing people to build their dream homes.

Neighborhoods in the small city include some homes that date back to the 1800s, and then on the same street are newly-built or remodeled homes that some argue just don't fit in with the area.

The Excelsior City Council determined that traditional zoning regulations haven't sufficiently preserved Excelsior's character and have failed to ensure that new homes are compatible with the neighborhood in which they're built, city documents state.

This led to the creation via the ordinance passed Monday of a Residential Review Process and Good Neighbor Guidelines, which require new builds, additions and remodels of single-family homes to be reviewed by the city's Planning Commission, architect and zoning administrator, as well as give residents who own property within 350 feet the opportunity to weigh in on the project prior to the city issuing a residential review permit.

Some small-scale projects that don't require a building permit are not subject to this process as they don't require a residential review permit, the ordinance notes.

Proponents of the ordinance, including the group Excelsior Forever, say it will ensure new houses fit in with their surroundings, preserving Excelsior's character and scale, which is why people chose to live there in the first place.

However, opponents, which include the group Unite Excelsior, have argued the guidelines are subjective and would negatively impact families, lower property values and discourage people from moving to the city.

Find a realtor using the Bring Me The News directory

The ordinance is not designed to regulate the architectural design of new construction and remodeling unless it affects mass, scale, bulk and/or orientation, documents say.

The residential review process ordinance wasn't the only zoning-related ordinance to pass on Monday. The City Council voted 5-0 to amend its ordinance related to landmark buildings within the city, allowing non-property owners to nominate single-family homes for landmark status so long as two people, including one resident, are part of the nomination.

If a landmark nomination is approved, the property owner has to get a special permit in order to do any major work to the exterior, the city's website says.

The change to the landmark ordinance came after a nomination was made by a renter, not a property owner, so it was rejected, the Sun Sailor reported.

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In Excelsior, neighbors now can have a say on whether you can expand your house - Bring Me The News

Two years after a Kennewick Taco Bell was torn down and rebuilt, a north Richland Taco Bellis gettinga makeover of its own.

Taco Bell,at1825 George Washington Way, istemporarily closed for an $800,000 makeover to bring it to the modern brand standards spelled out by Taco Bell owner Yum! Brands.

The updates include a down-to-the-studs interior remodel, electronic menu boards, more space in the kitchen and a new drive-thru, said John Arthur, president of Yakima Restaurants Inc., an Ohio-based company that owns and operates 32 Taco Bell franchises in Ohio andWashington.

Arthur manages the10 in Washington.

His identical twin brothermanagesthe Ohio ones.

The city of Richland issued permits on Aug. 21.

Taco Bell is one of two restaurants thatoperateinpadsat WashingtonPlaza,a Safeway-anchored strip mall at McMurray Street and George Washington Way. Sharis is the other. The complex was firstdeveloped in 1981.

Arthur said the exterior hasnt been significantly updated in the 30 years since itwasbuilt.Yum! Brandsnew standards for Taco Bell supplied the impetus to remodel, but he said Yakima Restaurants is going well beyond the minimum expected.

A bump out will add more space in the kitchen as well as storage space to better accommodate employees.

The restaurant is in the top 3 of the 10 Northwest locations for sales, he said.

It is also the mostaffected by the Covid-19 pandemic. Arthur attributes that to the loss of drive-by traffic since many Hanford site workers began working from home.

The restaurant will reopen in earlytomid-November as adrive-thru. Although restaurants can open at 25% capacity, Arthur wont reopen the dining room until it feels it is safe for employees.

About a third of the Richland employees are posted to the companys Road 68 location in Pasco. The remaining workers were laid off.

Arthur plans to remodel four Yakima-area Taco Bell locations in the nextone to twoyears.

Baxter Construction is the general contractor.

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Richland Taco Bell gets makeover, more square feet - tricitiesbusinessnews.com