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Church rebuilds a year after highway demolition | News | thefacts.com - Brazosport Facts

Attorney General, State of Delaware

Delaware Attorney General Kathy Jennings has obtained a preliminary victory for residents of the Pine Haven manufactured home community after the community owner, Blue Beach Bungalows DE LLC, was found to have violated statutory protections afforded to the residents.

An administrative hearing officer issued an opinion Thursday, April 4, finding that Blue Beach has willfully violated Delawares Consumer Fraud Act, among other laws, and ordered the company to pay more than $800,000 in penalties, along with rebates of excess rent paid by residents. Blue Beach has 30 days to appeal the order.

Owners of manufactured home communities should consider themselves on notice, said Jennings. Exploiting vulnerable Delawareans with threats and lies is not something manufactured home community owners can expect to get away with.

In April 2023, after receiving numerous complaints from residents, the AGs Consumer Protection Unit (CPU) issued a summary cease-and-desist order requiring Blue Beach to refrain from making false statements to residents and evicting residents in violation of the law, among other things. The cease-and-desist order was accompanied by a complaint detailing how residents were subjected to illegal rent increases, illegally threatened with eviction and arrest, and, in some cases, forced out of their homes prematurely. An administrative proceeding followed, culminating in an administrative hearing in September 2023.

The harm caused by [Blue Beach]s actions cannot be undone, the hearing officer wrote in a 90-page opinion issued on April 4. Despite being operated as a manufactured home community with numerous year-round residents, the park owner was found to have repeatedly made false and misleading claims as to the nature of the park as justification for taking action against residents.

The hearing officer ordered the park owner to rebate all tenants and former tenants any excess rental payments, and awarded an administrative penalty of $737,000 for willful violations of the Consumer Fraud Act, as well as a penalty of $94,000 for violations of the cease-and-desist order. The park owner has the option to appeal, and the order is not final until the window for appeal is closed.

A number of Pine Haven residents targeted for eviction by the park owner were protected due to a recent amendment to Delawares Manufactured Housing Code. 2022s House Bill 374, proposed by Jennings and sponsored by state Rep. Madinah Wilson-Anton, that expanded the definition of a manufactured home to include certain camper trailers, recreational vehicles, and motor homes.

Manufactured housing complaints can be made to the Office of the Manufactured Housing Ombudsperson on the Delaware Department of Justices website or by calling the hotline at 1-800-220-5424.

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AG obtains victory for manufactured housing residents | State | coastalpoint.com - Coastal Point

83 ANNA ROBERT CIRCLE, Wells $336,900 2 beds, 2 baths, 1,244 SF

Built in 2017 and situated in the Sun-N-Sea Village, this year-round home comes with a generator, shed, a deck and a little patio space. The listing says many upgrades have been made since 2022, including new lighting, plumbing fixtures and carpets. In the kitchen, you can see the new tile backsplash alongside white cabinets and a stainless-steel refrigerator. The water heater was added this year. Monthly association fees are $425. Represented by Patricia Berry, Better Homes and Gardens Real Estate The Masiello Group. See the full listing.

9 COLONY WAY, Kittery $389,900 3 beds, 2 baths, 1,387 SF

This home with a two-car garage was erected last year as part of the most recent expansion of the Yankee Mobile Home Community, with nearly 200 residences in mixed and 55+ neighborhoods. No interior photos have been shared, but the listing claims stainless steel kitchen appliances and blueprints show a mudroom, kitchen with breakfast nook, open concept living space, and a primary bed and bath placed is on the opposite end of the other two bedrooms and bath. Monthly association fees are $650. Represented by Carrie Alex, Keller Williams Coastal Realty. Off market.

69 COUNTRY WAY, North Berwick $495,000 3 beds, 2 baths, 1,746 SF

In addition to a whole house generator, two-car garage and landscaped yard, this circa 2020 house shows attention to detail in its design: recessed lighting, French and sliding barn doors, maximized closet space and a tiled shower. In the kitchen, find stainless steel appliances, a farmhouse sink and granite island, which the chef can look over to an open dining and living area. Located in the 39-lot development of Country Estates. Pets are welcome. Represented by Marie Burbank, Better Homes and Gardens Real Estate, The Masiello Group. See the full listing.

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Manufactured homes for 55+ buyers in York County - Press Herald

LINCOLN, DE - Delaware Attorney General Kathy Jennings has announced hefty penalties for the owner of the Pine Haven manufactured home community near Lincoln for alleged violations of Delawares Consumer Fraud Act and other state laws.

According to the Attorney Generals office, Blue Beach Bungalows DE, LLC, violated Pine Haven residents statutory protections through illegal rent increases, eviction and arrest threats, and forcing some residents from their homes.

An administrative hearing officer issued an opinion on April 4th, Jennings office says, that found Blue Beach willfully conducted these violations and ordered the company to pay over $800,000 in penalties as well as rebates of excess rent paid by Pine Hill residents.

The Delaware Department of Justice says Blue Beach has 30 days to appeal and the order is not final until the window for an appeal has closed.

Owners of manufactured home communities should consider themselves on notice, said Attorney General Kathy Jennings. Exploiting vulnerable Delawareans with threats and lies is not something manufactured home community owners can expect to get away with.

Jennings Consumer Protection Unit issued a cease and desist order against Blue Beach in April of 2023 after receiving numerous complaints from residents.

A recent amendment to Delawares Manufactured Housing Code which expanded the definition of a manufactured home to include certain camper trailers, recreational vehicles, and motor homes protected some Pine Haven residents targeted for eviction according to the DOJ.

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Over $800k in Penalties for Lincoln Manufactured Home Community Owner - WBOC TV 16

In a three-word social media post, the company shared an updated rendering of the future restaurant located in Barrio Logan that has sat vacant and abandoned.

SAN DIEGO The long-rumored Roscoe's House of Chicken & Waffles in San Diego County is back on, the company announced on Thursday.

In a three-word social media post, the company shared an updated rendering of the future restaurant located at 1678 National Avenue in Barrio Logan that has sat vacant and abandoned.

Fans of the legendary chicken and waffle destination began asking the question San Diego has asked for years: when?

Roscoes didnt announce an official opening date or an update on the construction that has remained idle for months.

"For real this time?? you keep playing with my emotions," one comment reads.

CBS 8 has been Working for You to find out what's going on with the long-rumored restaurant.

In December 2023, CBS 8 learned that the Roscoes Chicken and Waffles site in Barrio Logan was under investigation after the city received complaints that the construction site had been abandoned and had regular squatters with drug use occurring on the property.

"No security fencing around the job site," the complaint reads. "No daily workers to prevent squatters."

Its grand opening has been pushed back multiple times since 2016, much to the dismay of San Diego County residents who have been waiting for the California-based soul food restaurant chain's arrival.

In December 2023, a spokesperson with the franchise told CBS 8 that the Barrio Logan location is still slated to open but didnt specify when.

"Our team is diligently working to pass next inspections and get the green light from the city," the restaurant's spokesperson said.

CBS 8 reached spoke to San Diego's Development Services Department who said the project is still in the works.

Work at 1678 National Ave. is ongoing, with the most recent inspection having occurred earlier in 2023. Were here to work with them to continue progress on this anticipated addition to Barrio Logan.

Roscoes Barrio Logan location would have added to the seven Southern California franchises with restaurants in Long Beach, Pasadena, West Los Angeles, Inglewood, La Brea, Anaheim and Hollywood.

The soul food restaurant chain is known for its chicken and waffles dish, but also serves other soul food staples such as giblets, candied yams and grits.

WATCH RELATED: What's going on with the San Diego Roscoe's House of Chicken & Waffles?

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Roscoes Chicken and Waffles in San Diego could be opening soon - CBS News 8

The owners of two southern Maine mobile home parks have rejected an offer by residents who made a last-ditch effort to form a cooperative to buy the properties.

Instead, Seagate Limited Partnership has told the residents that it plans to move ahead with selling Atlantic Village and Old Orchard Village to an out-of-state buyer a decision that Old Orchard Beach residents feared would result in steep rent hikes or in the properties being repurposed into short-term vacation rentals.

After considering our options over the last few days, we have decided to pursue a private sale with the other buyer, Peter Pope and Sheldon Pope, two officials with the partnership, wrote Thursday in a letter to residents. This was a difficult decision for us.

Sandy Ossolinksi, a resident of Old Orchard Village who helped lead the residents cooperative bid, said she was not happy with the Popes decision but that she understood it. She said the 360 or so residents who live in the two parks found out about the sale after it essentially already had been arranged with the unidentified buyer.

I wish we had more recourse, Ossolinksi said. We could have jumped on the bandwagon a lot sooner had we known earlier the mobile home parks were for sale.

She and other residents of the mobile home parks held a Zoom meeting late Friday afternoon to discuss the situation. They expect to exchange more information with the Popes, she said, but dont have other options to pursue.

The Popes said in their letter that they had three main concerns about the residents proposal.

The first was that only roughly 50 percent of the parks residents signed a petition in favor of pursuing the cooperative plan, well below the 70 percent needed for the residents bid to get financing.

Second, the Popes said they are skeptical the residents could raise the $41 million needed to buy the properties.

Lastly, the Popes said they were not confident that they would be able to close on the sale if the residents wanted a 80-day period in which the residents could get their earnest money deposits back if they couldnt line up the financing.

Given these uncertainties, we feel as if accepting these terms presents too big a risk that we would be back at square one if the cooperative is not able to obtain the required financing, the Popes wrote in the letter.

The Popes said that the buyer they intend to sell to is a family business with 30+ years of experience operating communities just like ours. The buyer told the Popes that it would not redevelop the properties and that a planned rent increase on June 1, 2024, would be the only rent increase for the next 12 months, the Popes wrote in the letter.

Ossolinki said residents have been told their rents will increase by $75 a month after May. She said she is not sure when the sale will become final.

Ossolinski added that she feels the Popes have been good owners over the years, though maybe not all the residents would agree. She said she and other residents had been concerned that a big corporation would buy the parks.

I am relieved that its a family business, she said of the buyer.

If nothing else, the residents experience at the mobile home parks in Old Orchard Beach might be useful to residents of another other mobile home park in Maine that might be put up for sale, she said.

Im hopeful we can help the next group, Ossolinksi said.

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Owners of 2 Maine mobile home parks reject residents' bid to buy properties - Bangor Daily News

Ask About Our Community Buy Back Program Donate your old windows and doors that can be refurbished to help Central Westmoreland Habitat for Humanity Call us today for more details! Central Westmoreland Habitat for Humanity We are a Proud Partner We Care! MT. PLEASANT WINDOW & REMODELING CO. Doors Baths Windows Roofing Siding MT. PLEASANT Treating Customers like Family Since 1975! 2023 -2023- 2023 DEST best best WINNER 2023 WINDOW & REMODELING CO. We Care! Google 4.7 Multiple Categories & Awards, Winner 4 Years in a Row! Fully Licensed & Insured #PA003495 MTPLEASANTWINDOW.COM Call Today 724-200-8555 for a FREE In-Home Consultation Ask About Our Community Buy Back Program Donate your old windows and doors that can be refurbished to help Central Westmoreland Habitat for Humanity Call us today for more details ! Central Westmoreland Habitat for Humanity We are a Proud Partner We Care ! MT . PLEASANT WINDOW & REMODELING CO . Doors Baths Windows Roofing Siding MT . PLEASANT Treating Customers like Family Since 1975 ! 2023 -2023- 2023 DEST best best WINNER 2023 WINDOW & REMODELING CO . We Care ! Google 4.7 Multiple Categories & Awards , Winner 4 Years in a Row ! Fully Licensed & Insured # PA003495 MTPLEASANTWINDOW.COM Call Today 724-200-8555 for a FREE In - Home Consultation

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WEDNESDAY, APRIL 17, 2024 Ad - Mt Pleasant Window & Remodeling Co - Tribune-Review - TribLIVE.com

Laser ablation of the dorsal skinfold chamber (DSFC) microcirculation

The general patterns of skin microvascular remodeling were similar in all five mice studied (Supplementary Fig. S1, sFig. 1 and Supplementary Tables S1S6, sTables 16). sFigure 1 provides an extensive depiction of the time course and patterns of microvascular network remodeling observed in five distinct DSFC experiments, denoted as Rows AE, each row representing a separate animal experiment. For the in-depth analysis, we focused on Mouse E as a representative case. For this network, we performed a comprehensive anatomical data analysis and mathematical modeling. In sFig. 1, the locations of laser ablations are denoted by the circles (red, arterial; blue, venous). White crosses signify collateral outward remodeling from previously very small vessels, and blue crosses represent outward or inward remodeling of existing arterial/venous segments. Red and blue brackets indicate arterial and venous ablated segment reopening, respectively, and red and blue cross-brackets denote interruption of perfusion in arterial and venous segments, respectively. One to three ablations (except for mouse B D1+) were performed at select locations in the middle of the microvascular network in the largest visible arteries and veins. Remarkably, all specimens exhibit substantial remodeling at different time points from as early as days 13 (sFig. 1, Row B d1 and mouse C d3) and up to day 20 (mouse E, d20) and later (see below). In sFig. 2, mouse A, proximal venous ablation was bypassed through the development of an existing transverse venule, which underwent outward remodeling to match the initial vein diameter. The distal venous ablation revascularized by day 12, while the main vein initially underwent inward remodeling until day 12 and subsequently returned to its pre-ablation diameter by day 17. Arterial ablations and one venous ablation reopened by day 12 in mouse A. In mouse B, by day 5, venous ablations either led to bypass through outward remodeling of transverse veins (mouse C, d5, upper half) or caused inward remodeling of the main venous branch (mouse C, d5, lower half). Mouse C illustrates venous ablations bypassed by pronounced collateral development, while arterial ablation successfully revascularized. In mouse D, initial arterial and venous ablations reopened as early as day 2, while other ablations targeted the main artery and vein and two of their branches to induce flow changes during the period of observation. Mouse E showcases a combination of all remodeling patterns, albeit with varying time courses. Venous ablations revascularize through collateral growth, and arterial occlusions reopen. The majority of vessels display visible remodeling, and diameter data are further described and modeled in subsequent sections of the study.

The detailed diameter values are reported in sTable 1 for intact pre-ablation vessels and sTables 25 for remodeling time points reported in sFig. 1 for the proximal, medial, and distal regions from the closest ablation.

The primary observed remodeling patterns, which encompass outward/inward remodeling of existing arteries and veins, collateral growth of previously small vascular segments, segment reopening, and permanent segment occlusions, are summarized in sTable 6, with accompanying diameter data provided in sTables 25, and illustrated in sFig. 1. One of the notable findings was the presence of both outward and inward remodeling phenomena in both arterial and venous segments, a dynamic process that persisted throughout the observation period. From the onset, immediately after laser ablation at day 0 there were significant diameter changes as shown in sTables 25,although these changes are difficult to observe in sFig. 1. Starting at day1, there was visible collateral remodeling in most specimens.

Furthermore, sTable 6 also highlights the segment occlusion which was the goal of each initial laser ablation. While certain vessels maintained their occluded state throughout the observation period, a subset of vessels displayed the ability to gradually reopen over time. This observation indicates the dynamic nature of microvascular responses and their potential for adaptive adjustments over extended timeframes.

Due to variations in time course remodeling among specimens, a representative mouse (mouse E in sFig. 1 and sTables 16) was chosen to show the observed remodeling process for the remainder of the study. The typical mouse microcirculation within the DSFC contains a main artery and vein pair (Fig.1A,B, solid green arrowhead, and sFig. 1) and smaller arteryvein pairs (open green arrowheads). There are multiple arcade/collateral vessels that connect arteries to other arteries on separate branches of the arterial tree or veins to veins between venous branches. A few arterial collaterals are indicated by red and venous collaterals by blue arrowheads, respectively in (A). These arcading vessels provide vascular redundancy by allowing redistribution of blood flow. Arteries have significantly smaller diameters than the paired veins and have tighter concentric layers of smooth muscle cells (red and yellow in Fig.1, Pre-ablation 13 and Post-ablation 13).

The laser ablation was performed at three major locations (Fig.1A,B, two artery/vein pairs in regions 1 and 3, and an artery in region 2) in the center of the window to maximize blood flow redistribution and to allow long term observation of the developing vascular changes (as some drifting of the tissue occurs within the DSFC over two weeks). The ablated vessels experienced rapid vasoconstriction upstream and downstream from the ablation site (Fig.1, Post-ablation 13) as observed before25,26. There was complete blood flow interruption in segments just distal and proximal from the ablations (sVideos 1A, 2A and 3A). The laser ablation procedure was focused only on the target vessels, effectively cauterizing them while having little effect on the surrounding tissue as shown before in similar experimental settings26. The brown scar tissue located in the muscle fascia subsides at later time points (sVideos 1B, 2B and 3B). Note that in region 2, the ablation of the artery had no effect on the diameter of the adjacent large vein or the blood flow in that vessel (Fig.1, Post-ablation 2; sVideo 2A).

By day 6 after ablation, there was clear evidence of vascular remodeling throughout the network (compare Fig. 2D0/+and D6). Vessel segments associated with the ablated vessels had reduced diameter at day 6, while there was increased diameter in a number of collateral vessels (regions 4, 5 in Fig.2D6). By day 13, vessel diameters had qualitatively returned to pre-ablation values for much of the network (Fig.2D13). This was due to remodeling of collateral vessels, which allowed an increase in compensatory flow entering tissue regions previously supplied by the ablated vessels. There were also large increases in diameter in a few small vessels that restored flow through the veins by bypassing the ablation sites (arrowheads in Fig.2, D13, and sVideo 1AD, 3AD).

Time course of vascular remodeling post-ablation. D0- and D0+ indicate pre-ablation and post-ablation on Day 0, respectively. Regions 13 indicate the ablation regions and site (yellow line). Shown are images through Day 30 (D30). Initially, at Days 6 vessel redundancy and remodeling in areas compensate for the ablation-induced ischemia. By day 13, the venous connections were reestablished (clear and black arrowheads). From day 20, the artery in Region 1 has reconnected (green arrowhead) to mimic the original path, increasing flow to the downstream network. There was no angiogenic regeneration of the ablated veins; instead, flow quickly re-routed through small pre-existing venules that appeared to be pre-existing connections at either side of the damage site (clear and black arrowheads, D1330). The white scale bars are 1mm.

These structures formed from sequences of smaller microvessels that were part of the original vascular bed. It is likely that increased flow through these small bypass channels caused the expansion of vessel diameter which eventually matched that of the original vein, similar to previous observations in the mouse gracilis muscle2.

Some branches from the two small networks in regions 1 and 3 associated with the new vein segments appeared to be pruned or regressed as the new segments became part of the large veins. Albeit observed at low/medium resolution in transmitted light images, in these veins, there was no visible evidence of extensive angiogenesis or new vessel growth contributing to the regeneration of the network or restoration of flow. Rather, the rerouting occurred through remodeling of existing vessel segments, most of which could be visualized even before the ablations were performed.

However, we did observe reconnection of venous segments through the ablation site via endothelial migration in other networks (sFig. 1, rows AC and E). The response to injury appears to be related to the effective blood pressure difference across the ablation. In Fig.2, regions 1 and 3, the ablations are situated such that there is a large pressure drop across the ablation sites. This forces the blood to reroute through the smaller vessels early after the injury. However, in sFig.1 row A, there were two ablations performed on the same large vein. In this case, the upstream ablation has little pressure drop because the downstream ablation is preventing outflow. For this reason, very little flow re-routing or vessel remodeling occur at the upstream ablation, and this region was instead reperfused by direct reconnection of the vein via angiogenesis (sFig. 1, row A, d12 and d17).

On the arterial side, in region 2 we did not observe re-routing locally through pre-existing microvessels, and their subsequent enlargement, as in the veins of regions 1 and 3, Fig.2. Instead, flow was redistributed through the preexisting arterial arcades to circumvent the ablation and compensate for the lowered flow distal to the ablation sites (Fig.2. D6 and D13, areas 46, and sFig. 1C, d3 and d18). Compared with the venous rerouting in regions 1 and 3 in Fig.2, which occurred over very short distances (~1mm) around the ablations, rerouting on the arterial side extended over much larger distances (~510mm) through the arcade vessels. In the ablated arteries, we did observe reconnection of the vessel through the ablation site via angiogenesis to mimic the original path. On days 20, 23, 28 and 30, there was evidence of regeneration on the arterial side, as the artery ablated in Region 1 (Fig.2) reconnected (for example, see the arterial ablation in region 1 (Fig.2, D630, green arrowheads, and sVideo 1AD). As this new vessel segment grew, original flow through the artery was restored, and the diameters of the major compensating collaterals decreased (Fig.2, D28, region 8). The artery in region 2 (Fig.2, D630, yellow arrowheads) did not achieve reconnection by the 30-day time point although some small flow pathways can be traced (sVideos 2C and 3C). The arterial flow in region 3 was re-established by day 30 but via smaller vessels than the original artery (Fig.2, D30 blue arrowhead), with blood flow evident via Doppler OCT at day 14 (Fig.5, D14b) and intravital BF imaging at later time points (sVideo 3D).

Because of the endogenous reporters expressed by the mice, we were able to visualize endothelial cells (TIE2-GFPgreen) and smooth muscle cells (aSMA-dsRedred) longitudinally at the ablation sites. In vivo laser confocal imaging of regions 2 and 3 in Fig.1 revealed migration of the endothelial and smooth muscle cells through the ablation sites (Fig.3). In region 3, the vascular pathway was re-established, and blood flow was observed (Fig.3D). Both endothelial and smooth muscle cells migrated into the damaged region and appeared to establish a connection by day 30, based on Doppler OCT imaging (see Fig.5). A similar process was observed for the other artery, which was ablated at location 2 in Fig.1 (Fig.3A, B), although this vessel did not reconnect by the end of our observation period. Angiogenesis was not observed in the large vein that remodeled in region 3, but the remodeled region acquired a covering of smooth muscle cells (Fig.3C). After day 30, the relevant vessels had shifted out of the window chamber and were no longer observable.

Vessel regeneration at Day 30. At top is a brightfield image of regions 2 and 3 from Fig.1. Four regions are shown in detail with multiphoton imaging of the endogenous TIE2-GFP (endothelial cells) and aSMA-dsRed (smooth muscle cells). The ablated regions are shown by the circles. In these regions, there was evidence of angiogenesis in the arterial network as endothelial cells (solid arrowheads) and smooth muscle cells (open arrowhead) migrated into the ablated regions. At this time point, the remodeled vein segment in region 3, Fig.1 has matured, with a covering of smooth muscle cells (arrow, C). The scale bar is 1mm.

Overall, both arteries and veins changed their diameters collectively over time (Fig.4 and sFig. 1 and sTables 26). Because of resolution limitations, we restricted the quantitative analysis to the main arteries and veins and their transverse branches with inner diameters larger than 11m; therefore, the histograms do not include smaller vessels and capillaries. The smallest arteries (30m centered bin) stayed almost constant during the time points studied. A small dip at day 6 was recovered and slightly increased at the later time points. Combined with changes at other time points this could mean that smaller vessels became larger and therefore visible in this diameter range. The largest change in diameter distribution was observed in the 60m bin which was increased at days 620 and went back to normal values by day 30 which suggests a transient increase in vessel diameters to accommodate the early changes in blood flow as we noticed before in the gracilis artery remodeling2,4. Some larger vessels also constricted, moving from the 90150m to the 60m range. At day 16, this trend reversed temporarily while between days 2028 a lot of the larger arteries were still constricted. By day 30 diameter distribution of all arteries was close to post-ablation and pre-ablation values even in the absence of the ablated large artery suggesting that blood redistribution can be accomplished through the contribution of the network of smaller arterioles even in the absence of the large artery.

The frequency distribution of vessel diameter for arteries (top) and veins (bottom) pre and up to 30days post-ablation. Post-ablation, the distribution of artery diameters is skewed towards more smaller diameter vessels suggesting the blood is redirected from large arteries to smaller alternative pathways. This trend is reversed towards a more normal distribution (more larger vessels) past day 16. On the venous side, the distribution of diameters is more stable reflecting a larger capacity of the venous side to accommodate blood flow redistribution without major diameter changes in most of the vessels.

The vein diameter distribution is more spread over a larger range of diameters suggesting a larger adaptation of the veins to accommodate flow changes. The largest variation in diameter distribution was observed in the 30m bin although a slight transient tendency is also observed between days 6 and 28 with a decrease to normal values at day 30. During the transient increase period, an interesting second transient decrease was observed at day 16. Veins in the 80m range exhibited a gradual increase starting from post-ablation and peaking at day 30. The veins with diameters in 130180m range showed the largest increase in density at early and medium time points (days 6 and 16). The largest veins stayed open immediately following the ablation, at day 6 they were reduced in diameter, at days 16 and 20 they were close to normal values but by day 30, the number of larger veins was drastically reduced suggesting again that on the venous side like the arterial side, flow redistribution could also be accomplished via a larger network of smaller venules.

We next focused on individual vessels to determine how specific vessels contributed to the flow redistribution. Using quantitative flowmetry OCT methods based on amplitude-decorrelation which can be used to estimate flow rate as well as lumen diameters30,31, we analyzed a number of segments distal and proximal to the ablations sites before and following the ablations (Fig.5). We also used intravital BF microscopy to determine flow directions (see Supplementary Videos S1S3). In the intact network, the blood flows from left to right from the large artery (#2, Fig.5) to its branches (#4, 6 and 9). The blood flows from the venous branches (#3, 5, 7, 8,10 and 11) towards the main vein (#1). Following ablation, the blood flow stopped in the ablated segments, but both upstream and downstream arteries continued to be perfused by arcading vessels from adjacent vascular trees (#2,4,6 and 9). Immediately after and at day 2 post-ablation, the segments near the ablations were not perfused. Nonetheless, at day 14, there is a signal of blood flow (Fig.5, D14 green arrowheads) confirming the data from bright field microscopy (green arrowheads in Fig.2, D630). The arteries upstream from the ablation (#2 and 4) have a decreased diameter and flow velocity during the first few days post-ablation while the more peripheral arteries (#6 and 9 with reversed flow as observed experimentally) increased their diameters from day 2 post-ablation and through day 14, suggesting that they are largely responsible for the compensatory flow being rerouted from the parallel arteries (which are outside of the field of the window).

Blood flow visualized by decorrelation-based quantitative flowmetry OCT before ablation (D0), just after ablation (D0+) and on days 2 (D2) and 14 (D14). The three ablation sites are marked with blue circles at D0- (see also Fig.2 D0 and D0+). Areas in the blue boxes at D0 and D14 (a, b) appear at bottom at higher magnification. Immediately post-ablation, flow is completely interrupted in the segments just downstream from the ablations and diverted to alternative pathways. The venous connection in left side ablation site (circle 1 in Fig.2 D0 and D0+) is reconnected by day 14 while the arterial segment is not reconstructed. The flow is reversed in artery 6 which received blood from the bottom vascular network from day 0 to day 30 when the direction of flow is restored to pre-ablation direction from the large artery segments 2 and 4 towards segment 6 (Supplementary Videos S1S3). Venous segment 10 remodels close to 400% from a venule to a major vein. Smaller post-capillary venules also appear to be involved in this rerouting of flow (arrowheads). By day 14, angiogenesis has partially reconnected the artery in this region, and some flow is evident (arrow, b).

The main vein (#1 and 3) significantly decreased its diameter on day 2 but by day 14 the main vein and its small branch (#10) as well as a contiguous series of microvessels became enlarged to match the size of the vein (Fig.5a,b). Venous branch #5 maintained its diameter throughout the 14-day time course, as its flow was not directly affected by the ablations, and exit flow proceeded through the main vein through this pathway. After the ablation, flow through vein #7 was rerouted through vein #8, causing flow reversal in this vessel (Supplemental video S3A). Once the connection between these segments and the main vein was reestablished, the flow direction in vein #8 returned to normal (Supplementary video S3B). These changes in flow direction and topology resulted in large changes in diameter and flow rate in this region (Fig.5, D14). A side branch, venule #10 was affected little by the ablations, and maintained exit flow through the main vein. The ablation completely stopped exit flow in vein #11 by day 14, the connection is rerouted, and flow and diameter are returning to pre-ablation levels.

Diameter measurements at later time points show that main artery segments #2 and 4 recover after the initial diameter decrease probably due to vasoconstriction caused by the ablation. They continue to remodel outwards from day 1628 with a transient dip at day 14 (Fig.6 top histograms). The transverse arteriole #6 diameter increased throughout the time course although the flow direction changed (Supplementary videos S2AC). Despite interruption from the main artery 52, its distal arteriole branch #9 had undergone outward remodeling (with a transient lower rate at day 13) due to collateral and reversed flow from adjacent arterioles.

Time course of diameter changes for the representative vessel segments imaged by OCT (see Fig.5). The venous connection in area 1 is re-established by day 14 while the arterial segment #2 is not reconstructed. The flow is reversed in artery 6 which received blood from the vessels of the distal network at the bottom region of the Figs. 1 and 2. Venous segment 10 remodels close to 400% from a precapillary venule to a major vein.

The main vein segments #1, 3 and 8 remodeled inward at early time points and then outward from day 14 on. The transverse venules #5 and 7 remodeled outward, likely to compensate for the main vein interruption. Interestingly, the distal part of the small venule #10 remodeled outward rapidly to match diameter and re-route flow to the main vein. Its diameter increased by 40% at day 6 to 221% at day 13, 229% at day 14, 306% at day 16 and 343% at day 20. Vessel #10s outward diameter remodeling peaked at day 23 at 379% increase from normal (close to 400%) and decreased by the end of the observation period at day 28282% of the original diameter at day 23, suggesting a possible transient remodeling (Figs. 5b, 6, venous segment #10).

The specific diameter changes and patterns of remodeling were observed in detail in five specimens. The present data demonstrated that microvascular remodeling patterns are similar and reproducible but differ in detail from mouse to mouse (sFig. 1 and sTables 26). The comprehensive data presented in sTable 6 not only underscores the diversity of remodeling patterns but also the intricate and adaptive nature of microvascular networks in response to laser ablation, offering valuable insights into their behavior and potential clinical relevance.

sFigure 1, in conjunction with sTables 26, provides a comprehensive insight into the dynamic behavior of microvascular networks in response to laser ablation. The figures and data within sFig. 1 offer a detailed visual representation of the time course and various remodeling patterns observed across five distinct animal experiments (Mice AE). These patterns include collateral outward remodeling, reopening of arterial and venous segments, and instances of permanent segment occlusion. We have noticed isolated tortuosity in some of the observed vessels (sFig. 1B day 5 and C day 18) although not as extensive as it was noticed before. The selection of Mouse E as a representative case for in-depth analysis in sFig. 1 serves to illustrate consistent changes seen across all mice while supplying essential anatomical data for subsequent biological and mathematical modeling endeavors. sTable 6 complements this by summarizing the observed remodeling patterns at different time points, highlighting the persistence of both outward and inward remodeling in arterial and venous segments throughout the observation period. Additionally, the findings emphasize the network's remarkable adaptability, with the ability to achieve persistent occlusion over the period of observation in some vessels while also demonstrating the capacity for gradual reopening over time in others. Together, sFig. 1 and sTable 6 could offer critical insights that have relevance for both experimental investigations and potential clinical applications.

We next investigated flow patterns in the network before and after the ablations. To do this, we used a computational approach to estimate flow in each segment. The first step in computational modeling is extraction of the network topology and characterization from bright field images taken with the stereo microscope (Fig.7). The venous network roughly parallels the arterial network with visibly larger diameter vessels. The direction of the flow for each segment was observed from the live BF microscopy recordings and marked on the network map (Fig.7a,b).

Vascular network topology and flow patterns. The arterial (a) and venous networks (b) are traced separately based on intravital images, and digitized versions are extracted. The observed flow directions are indicated by arrows.

We then used a simulated annealing method to estimate flow rates and pressures throughout the network (see Methods). Guesses are made for the terminal segment pressures, and the flows are calculated based on topology and measured vessel diameters. The predicted flow direction in each segment is compared to the observed direction, and an error function is calculated based on the number of incorrect directions. The error is used to scale a set of new guesses for the pressures, which is also subjected to a random function (this is the basis for the simulated annealing method). The process is then repeated to minimize the number of incorrect flow directions in individual segments. Using this method, we find that most large vessels have flow that varies little between trials (blue in Fig.8), but that flow direction in a few vessels (red in Fig.8) is relatively uncertainshowing a high sensitivity to distant changes in pressure. This suggests that these vessels can readily serve as collaterals that are available to redirect flow in either direction if necessary.

Computational model results of the pre-ablation network. Flow rates have been normalized relative to a value of 1000 assigned to largest vessel segment located on the left side. (AD) The histograms show the frequency of flow rates in representative vessel segments obtained from 100 runs of the simulated annealing algorithm. Numbers in the network map show the average flow rate for each segment, calculated over the 100 runs. The network map is color coded to show the relative uncertainty (standard deviation/mean) of the flow rates in each segment.

First, the flow distribution of individual vessels was optimized based on network topology and flow directions in the normal non-ablated state for vessels with different levels of uncertainty/flow levels (Fig.8). Before ablation, the larger arteries have low uncertainty, suggesting that they rarely change flow direction (Fig.8, blue and yellow color vessels). For example, the vessel fragment in Fig.8, panel C has a low level of uncertainty (indicated by blue color on the vessel map) and the relative values of the volumetric flow rate are mostly around 20% of that in the largest vessel (which is assumed at a value of 1000). The segments with the highest uncertainty mostly carry lower flow and are located near the center of the network (Fig.8, red and orange color vessels). To illustrate this point, vessel fragments in Fig.8, panels A, B and D have a higher uncertainty (orange and red on the vessel map) and therefore a wider range of possible values. Note that the segments in panels A and B stabilize at zero or close to zero values which reflects a low priority for these collateral vessels prior to ablation.

Using this method, we estimated flow through the network before (Fig.9A,C) and after ablation (Fig.9B,D) for arteries and veins, respectively. The venous network had more segments with higher flow rate pre-ablation (Fig.9, C vs. A). In arteries, after ablation, flow tends to be reversed in vessels with a high uncertainty index in the pre-ablation model close to the site of ablation (Fig.9). There was no flow reversal in the vein network although the flow magnitude was slightly changed in many vessel fragments.

Computational model results of the pre- (a and c) and post-ablation (b and d) networks. Numbers in the network maps indicate flow rate. The arterial network (a and b) had fewer fragments with high flow rate uncertainty than the venous network (c and d). However, flow reversal was common in the arteries but not the veins.

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Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following ... - Nature.com

New U.S. housing starts plummeted in March, dropping 14.7% below the revised February estimate of 1.55 million to 1.32 million and 4.3% below the March 2023 rate of 1.38 million. The shift marks a drastic downturn compared to expert estimates heading out of February, which itself saw new construction numbers hit two-year highs, spiking 10.7% from January.

Analysts had originally predicted the rate for March to fall around 1.48 million.

The drop in March 2024 is being compared to the decline seen in April 2020 when new housing starts dropped by a staggering 27%. Outside of the pandemic, this is the most housing starts have dropped since February 2015.

The northeast took the biggest hit, with new single family housing starts dropping a whopping 40.9% in March. Across the board, however, most regions were down with the Midwest 14.5% lower, the south 12.9% lower, and the west being the only region up at a measly 1.3% from February.

Multi-family (MDU) construction took a similar hit, with overall starts dropping 20.8% from Februarys numbers.

New housing permits also declined heading into March at a rate of 1.46 million, 4.3% below the revised February rate of 1.52 million. They did, however, remain slightly above the March 2023 rate1.5% to be exact.

Builder sentiment overall remains unchanged, however, as many have a small level of optimism despite predictions that the rate of new homes being constructed expected to continue to drop.

According to NAHB Chief Economist Robert Dietz, Aprils flat reading suggests potential for demand growth is there, but buyers are hesitating until they can better gauge where interest rates are headed.

Despite experiencing a slight dip at the beginning of the year to below 7% on optimism of a March rate cut, mortgage rates have steadily continued to climb and are now moving back towards that 7% mark on news of persistent inflation in a hotter than expected market that may now push rate cuts back towards July at the earliest.

Currently, YoY inflation sits at 3.3%, still above the Feds target of 2%, which has led to a more conservative stance in introducing rate drops.

To combat the ongoing affordability issues, homebuilders have continued to offer price cuts and other incentives to first time home buyers to increase sales while also diversifying into smaller, more affordably built homes to account for the high price of materials.

The number of homebuilders cutting prices has dropped, however, to 22%, down from 24% last month. Sales incentives, likewise, have decreased from 60% down to 57% this month. The average price reduction of homes is remaining steady though at 6% for the tenth straight month.

Inventory, howeveror lack thereofcontinues to be the buoying force to homebuilder sentiment, as an overwhelming lack of existing homes has led to newly constructed housing being the primary source of home inventory for many homebuyers.

This lack of existing inventory has also led to similarly optimistic views on the remodeling market, with the NAHBs most recent Remodeling Market Index (RMI) giving a 66 reading (with 50 marking a neutral sentiment). The index runs from 0 to 100.

Demand for remodeling remains solid, especially among customers who dont need to finance their projects at current interest rates, said NAHB Remodelers Chair Mike Pressgrove, a remodeler from Topeka, Kan. Construction costs are still an issue in some places, just as they were toward the end of last year.

The Current Conditions Index also averaged 74, remaining unchanged from the previous quarter and indicating strong positive sentiment overall for the demand of remodeling projects across all price ranges which include $50,000; $20,000 $50,000; and below $20,000.

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New Housing Starts Plunge in March, Remodeling Sentiment Remains Positive - CE Pro

MONTERREY, NL - After supervising works at the Monterrey International Airport, Samuel Garca, Governor of Nuevo Len, assured that the remodeling works will be delivered in a month.

The governor pointed out that it will be a first world airport, putting Nuevo Len and the country at the top.

"Exactly in one month, according to what I was told, we are going to inaugurate the remodeling of the Mariano Escobedo International Airport, which I have already seen the video, I have already seen the renderings, the space and the truth is that it will be a first world airport like no other in Mexico," he assured.

It was in July 2023, when the government of that state announced the expansion of the three new traffic lanes for this terminal. As well as the rehabilitation of the asphalt surface, in addition to improvements in the signage of the base area.

Monterrey International Airport is used by more than 18,000 cars on average and these works, according to the authorities, are part of the mobility plan that will be ready for the 2026 World Cup, where the capital of Nuevo Leon will host different soccer matches.

The implementation of the project involves a cost of US$17 million, which includes the remodeling of Terminal A, B and C, optimization of runways, taxiways, platforms, as well as equipment.

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Monterrey Airport remodeling to be ready in one month - MEXICONOW