Home Builder Developer - Interior Renovation and Design

PUBLIC RELEASE DATE:

29-Oct-2014

Contact: Chris Chipello christopher.chipello@mcgill.ca 514-398-4201 McGill University @McGillU

A new study on a large cohort of kidney cancer patients in Europe sheds light on the genetic architecture of the disease -- and reveals an apparent link between exposure to aristolochic acid and incidence of kidney cancer, particularly in Romania.

The research, by an international team led by scientists from the McGill University and Genome Quebec Innovation Centre in Montreal, underscores the importance of investigating possible sources of exposure to aristolochic acid. The compound, found in plants of the Aristolochia genus, also has been suspected of causing a kidney disease known as Balkan endemic nephropathy, affecting people along the tributaries of the Danube River in Croatia, Bosnia and Herzegovina, Serbia, Bulgaria and Romania. Aristolochia clematitis, or European birthwort, is a common plant throughout the Balkans.

Results of the study, which focused on the most common form of kidney cancer clear-cell renal cell carcinoma -- are reported today (Oct. 29) in Nature Communications. Renal cancer accounts for 2.4% of all adult cancers and more than 140,000 deaths annually. Incidence rates have been increasing sharply, with the highest rates occurring in Central Europe.

The researchers performed whole-genome sequencing on DNA isolated from blood and tumour tissue samples and RNA sequencing on tumour and matched normal tissue samples taken from a total of 94 kidney-cancer patients in four countries: the Czech Republic, Romania, Russia and the United Kingdom.

"The most striking observation was the high frequency of a specific type of mutation pattern found in the Romanian patients," says Yasser Riazalhosseini, an assistant professor of genetics at McGill. "The specific sequence context surrounding these mutations and their predominance on the non-transcribed strand of DNA enabled us to hypothesize that the mutation is due to exposure to aristolochic acid during the patient's lifetime."

This same mutation pattern is found in patients suffering from urinary-tract cancer associated with Balkan endemic nephropathy. That disease is thought by many scientists to be due to consumption of wheat flour contaminated with seeds of Aristolochia clematitis. Aristolochic acid is also used in herbal remedies in parts of Asia.

"While the study included only 14 patients from Romania, the specific mutation pattern was found in 12 of them. As a result, we will analyze samples from more patients from Romania and elsewhere in the Balkan region, in follow-up research that is now underway to assess the extent of exposure," says Professor Mark Lathrop, scientific director of the McGill University and Genome Quebec Innovation Centre, who led the study.

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Study sheds light on genetic architecture of kidney cancer

PORT CHARLOTTE, Fla.- In an effort to keep Southwest Florida's water clean, residents are being told they need to shell out $10,000 to convert their septic tanks to county sewer.

Most of the area affected is in the Spring Lake community.

"We believe it's going to improve the water quality in Charlotte Harbor," said engineer Bruce Bullert.

Homes that have septic tanks will be required to hook up to the county sewer.

The county will receive a total of $3.3 million dollars in grants from the state.

"A lot of these homes were built a number of years ago. A lot of the on-site systems are really quite old and because of that, a lot of them have seen their life," said Bullert.

"We had the option of the sewer or the septic so we took the sewer," said resident Richard Martin.

Unlike Martin, many of the approximately 1,500 homeowners that live in the area northwest of the Spring Lake boatramp will have to pay to transfer from septic to county sewer.

Many homeowners say they cannot afford the change.

Utility officials say they are looking for ways to help reduce the cost.

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Port Charlotte residents must pay to switch to county sewer

YORKSHIRE Water is appealing for information over the illegal discharge of waste into the public sewer network at Sinnington.

An unknown tanker is understood to be parking near Elmsall House Farm at about 10pm and discharging what appears to be septic tank waste or grease trap waste.

The illegal discharges are blocking the pumps at the sewage pumping station, causing the station to fail.

Fran Winter, for Yorkshire Water, said their contractors were having to to clean the pumping station out monthly.

We are not sure who is making these illegal discharges, but there are only a select number of companies authorised to carry out work at this pumping station and the network and they would not be there at 10pm unless the pumps blocked at night and then there would be a Yorkshire Water vehicle there too, he said.

Anyone who sees anything suspicious should make a note of the date, time, location and vehicle and phone 07790 617817 or email frances.winter@yorkshirewater.co.uk

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Yorkshire Water's appeal for illegal waste information

Growth in residency has created a need for Uintah Care Center to take out parts of their lawn and build an addition onto the building. The addition has allowed Uintah Care Center to have the room to remodel as well, creating a recreational area in an already existing room.

Wayne Dunbar, Uintah Care Center Administrator, said the remodel was needed because the new clientele coming into the care center.

The baby boomers are coming in and the baby boomers like to be in a nicer setting when they come in for a short stay rather than mixing them with the rest of the population, Dunbar said.

The new addition has 14 private suites which were designed to be more like a hotel room with a bed, refrigerator, table for a computer, private shower and television, as well as a lift chair to help the resident get up and down.

It's all the comforts of home, Dunbar said. Then they have a dining room they can come down and eat or even in their room.

The baby boomer clientele not only has a new dining room but also a living room area where they can visit with family and friends, complete with a fireplace. The new area also has a vast room which can be closed off with dividers to make three rooms, depending on the need for the day's activity.

On the other side of the building there used to be a day care but the day care but the day care business wasn't any good anymore after 2000, because there was no federal funding, so it became like a multipurpose room, Dunbar said. We want it to be a living space now so we created this space (the open hall) to replace the old space. We have about 3,000 square feet here, a kitchenette for activities.

Commissioner Darlene Burns was present Wednesday afternoon for the open house, showing the public as well as residents the new portions of the building, which was contracted using an award winning design.

This is such a nice facility for our county to have, Burns said. One thing that is good for our county is it is paid for.

Burns said it is great to have a Care Center locally so people can stay close to home instead of leaving the area for assisted living.

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Uintah Care Center adds new suites, accommodations

Terry Farrell

Record Staff

One of the longest-running fundraising traditions in the area happens Sunday at the Sid Williams Theatre, with the 39th edition of the CVCDA Telethon.

But what exactly is the CVCDA?

The Comox Valley Child Development Association is an all-in-one centre for all things related to childhood development.

From the Infant Development Program and The Autism Program, to occupational therapy, physiotherapy and speech-language pathology, to pre-natal support, and even support for grandmothers involved in childcare, the CVCDA really does have it all, in regards to the development of children. And best of all, the costs are covered.

There is no cost for the services here, it is all funded by the provincial government, said CVCDA executive director Joanne Schroeder. There can be additional costs, for equipment, or respite services...but there are always options and we always work so that costs are not a barrier.

A relationship between a family and the CVCDA starts with Kim Griffiths, the associations family resource consultant generally the first contact a parent has with the CVCDA.

Once a family gets referred here, I go out and meet with them, and determine whether theres a service that is appropriate for them if there is some type of program we offer that is beneficial to the family, said Griffiths.

Chances are, the CVCDA has the tools and people - to help.

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Comox Valley Child Development Association: One stop for child development needs

Some essential items were delivered to Iron Hill Brewerys newest location in Ardmore Tuesday.

Those would be the seven fermenters, eight serving tanks and brewhouse equipment that arrived on two trucks at the restaurant under construction at 60 Greenfield Ave. in the Ardmore Plaza Shopping Center.

Once those elements are installed and permitting completed, the brewing will start, in advance of an early December opening. Company President Kevin Finn, who was on site for the process, said the target date is Dec. 12.

Today were unloading the brewery, he explained Tuesday morning. Thats always an exciting day for us. It means were in the home stretch.

It is a process that, with the Ardmore store, Wilmington-based Iron Hill will have completed 11 times since 1996 at locations in Delaware, Pennsylvania and New Jersey.

Finn explained that, as in the other locations, nearly all of the beer that will be served in Ardmore 99 percent -- will be brewed on site. In this case, that will be under the direction of Ardmore Lead Brewer Paul Rutherford. The brewers will do some trading between locations, he said. They might exchange a couple of kegs.

Brewing, which can be done in batches of about 264 gallons with the 10 hectoliter tanks that arrived this week, differs with the beers.

Ales take 10 days to three weeks, some a little longer, Finn said. Lagers take three to five weeks to ferment.

The lager yeast works at colder temperatures. Its not as active. Thats why you often see most brewpubs doing ales, but Iron Hill made a commitment to do some lagers from the beginning, he added.

The restaurants also typically offer a porter, an IPA, a Belgian witbier and a raspberry wheat beer, with seasonal and other specialties of the brewers. Continued...

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Brewing equipment moved in to Ardmore's new Iron Hill Brewery

by Shawn Campbell

KMOV.com

Posted on October 29, 2014 at 11:39 AM

Updated yesterday at 11:47 AM

MANCHESTER, Mo. (KMOV.com)- Plans to demolish a building built in the 1890's on Manchester Road to make way for a Culver's restaurant have been approved by the Manchester Board of Alderman.

The alderman met Oct. 20 and voted unanimously to grant a special use permit to Valerie and Daniel Siemer of VHSDPS Restaurants Inc., of Creve Couer, to construct a 3,900-square-foot Culver's restaurant and drive-through lane at 14432 and 14444 Manchester Road.

They hope to open the $3 million restaurant next summer.

In order to erect the restaurant, builders will first demolish the former Staebell's Hotel and Saloon, which is currently vacant on the site.

The planned demolition drew no opposition during the alderman's Oct. 20 meeting.

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Culver's construction to demolish 1890's building

Pyongyang, October 29 (KCNA) -- Supreme Commander of the Korean People's Army Kim Jong Un, first secretary of the Workers' Party of Korea and first chairman of the National Defence Commission of the DPRK, together with Ri Sol Ju gave field guidance to the newly built restaurant for service personnel.

Watching the restaurant, Kim Jong Un recollected with deep emotion the immortal exploits performed by President Kim Il Sung and leader Kim Jong Il.

He recalled that the restaurant for service personnel which opened in February 1948 on the personal initiative of the President gave service without interruption not only in the period of building a new country but also during the Fatherland Liberation War and it successfully ensured a banquet celebrating the war victory day which was honored with the presence of the President.

Thanks to Kim Jong Il who personally took a measure for providing foodstuff to the restaurant even in the period of the Arduous March when the country was undergoing great difficulties, the restaurant has always been opened, he said, adding that the service personnel of the KPA will always remember the warm loving care shown by Kim Jong Il.

Noting that the restaurant has satisfactorily played its mission and duty as a catering center for service personnel for the past several decades, he instructed the officials and employees of the restaurant to serve them well so as to convey the profound loving care of Kim Il Sung and Kim Jong Il to posterity.

He went round different places of the restaurant including dining rooms and kitchen to learn in detail about its construction and service plan.

He said all dining rooms look spacious and nice to be fit for catering facilities, interior decoration is peculiar and the color of finishing building materials look attractive, adding that they are so impeccable that they can be used as a state banquet hall.

He was pleased that the restaurant has quality tables, chairs and other furniture, the kitchen was arranged well to be fit for its capacity and it has sufficient utensils including noodle-trays in place. He was satisfied with its modern sterilizing and washing equipment to fully ensure hygienic safety, in particular.

He set forth the tasks to be fulfilled by the restaurant for managing and operating it and improving its service.

Underlining the need for the restaurant to develop itself into the one frequented by service personnel, he stressed that to this end it is most important for its officials and employees to provide kind service and display cultural traits and, at the same time, strive hard to improve the quality of noodle in the spirit of devoted service to service personnel.

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Kim Jong Un Gives Field Guidance to Newly Built Restaurant for Service Personnel

Helping Home owner done all rights Home Improvement and remodeling
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Helping Home owner done all rights Home Improvement and remodeling - Video

Lars Remodeling - water pressure at kitchen sink
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Lars Remodeling - water pressure at kitchen sink - Video