16 January 2021, 12:22 | Updated: 16 January 2021, 14:16

Pimlico Plumbers chief Charlie Mullins reveals he won't employ anyone who hasn't been vaccinated against Covid-19, once the jab is widely available.

"It's an employers right to protect and look after their employees[...]and that's what we're doing," said Charlie Mullins, founder of Pimlico Plumbers.

He told Andrew Castle that he believes "if you're in a position to have a vaccine, you should have it," adding that he will not put his staff and customers at risk unnecessarily.

"In the future once the vaccination is circulated correctly...we won't be taking on anybody that hasn't had the vaccination."

Andrew argued that Mr Mullins' policy can be seen as discriminatory, but the entrepreneur insisted that health and safety policies are on his side.

Read More: Young people may have to stay in lockdown until vaccinated

Read More: Covid-19 crisis in numbers: LBC brings you the stats you need to know

"We're not prepared to bring people into the building that have not been vaccinated," Mr Mullins insisted, adding that "safety is the priority here."

He reiterated to Andrew that it is not only a policy of protecting customers, he insisted that "we need to protect our employees."

Finally, Andrew wondered if Mr Mullins thought it should "be mandatory in society to have the vaccination?"

"I think that's what it's going to lead to," Mr Mullins concluded.

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'I won't employ anyone that refuses vaccination,' claims plumbing boss - LBC

One of Moderna co-founder Derrick Rossis favorite things to say is that there are three keys to life on Earth: DNA makes mRNA makes protein makes life.

The experimental technology behind Moderna and Pfizers coronavirus vaccines harnesses the power of one of those keys messenger RNA, or mRNA. They are the first medical products to use mRNA in this way, but they certainly wont be the last. A Covid-19 vaccine is just one of the near-infinite possibilities the technology offers, Rossi said.

Being able to control mRNA would allow scientists to manipulate life in astonishing new ways. It could open the door to new treatments for diseases like cystic fibrosis, cancer, and HIV. Now, bolstered by the apparent success of the Covid vaccine, Rossi said, those other applications may soon come to fruition.

Within 10 years time, well see probably dozens of mRNA therapeutics. In maybe 15 years time, well see maybe 50 or 60 mRNA therapeutics, he said.

Before Rossi co-founded Moderna, he was a biologist at Harvard tinkering with mRNA. DNA is often described as the building block of life, but DNA is essentially a database of information cells need to create proteins. RNA is the molecule that actually does the work of creating those proteins.

For years, Rossi and other scientists tried designing strands of mRNA that would force cells to make specific proteins. But long before this technique created the worlds highest profile vaccines, they failed.

It totally didnt work, Rossi said. What it looked like to the cell was that the mRNA was a virus. And the cell, like a good soldier, would elicit a very robust antiviral response.

Every time Rossi tried to insert the mRNA, the cell would either destroy the molecule or kill itself not at all what he wanted. He felt like hed hit a wall. The solution came from another part of the cell and two scientists at the University of Pennsylvania discovered it.

Katalin Karik, then a junior scientist at UPenn and now a senior vice president at BioNTech, another company that has developed a Covid vaccine, was trying to do the same thing that Rossi was and coming up empty, too. But a colleague of Karik at UPenn, Dr. Drew Weissmansuggested that Karik try using modified chemical letters in her mRNA code.

By modifying the RNA, it cloaks the RNA. Its like giving it a fake passport, said Timothy Springer, an immunologist at Boston Childrens Hospital and Harvard Medical School. And it worked brilliantly.

The modified chemical letters disguised the mRNA, making it appear more or less innocent to the cell. When Rossi read about Karik and Weissmans work, he immediately startedincorporating their technique into his own research. In one experiment, he directed cells to create proteins called Yamanaka factors that converted mature cells into stem cells. In another, he injected mice with mRNA encoded for the protein that makes fireflies light up.

And then you know, an hour later, we put the mice into this machine, and we could see this glowing spot, Rossi said.

The experiments were working, and now Rossi knew how to control one of the three most fundamental keys to life. He took the new data to Springer, also an accomplished entrepreneur, and asked him to help start a company based on the new technology.

Springer jumped on board, becoming the companys first investor. They called it Moderna short for modified and RNA. Both still own stock in the company.

The possibilities were unlimited, Springer said. You know, the RNA can encode for anything. They could be encoding secreted protein or an enzyme in the cell or a vaccine unit, you know, to protect against SARS-CoV-2.

Over the last decade, Modernaand other companies like BioNTech have been studying modified mRNA technology as a way to develop treatments fora wide variety of diseases including heart failure and chikungunya virus. Other researchers have found ways to use modified mRNA to makeadvancesin anti-aging research.

And modified mRNA is particularly suited to creating vaccines, Springer said. Thats because while those modified chemical letters allow the molecule to sneak past cellular defenses, the compoundstill looks somewhat suspicious. It doesnt completely sneak by, he said, theres a little bit of interest. Maybe the eyebrows of the immune system perk up.

The mRNA in a vaccine carries the code for a pathogen protein like the spike protein from the coronavirus. When the cell begins executing the code from the vaccine and manufacturing that protein, the already wary immune system flares into action and produces a particularly strong immune response. That might be one reason why the coronavirus vaccines from Moderna and Pfizer have beenso effectiveso far in clinical trials, Springer said.

That property, along with others, makes modified mRNA an attractive option for cancer vaccines, said Dr. Cathy Wu, an oncologist at the Dana Farber Cancer Institute. These vaccines train the immune system to attack tumors, but creating them takes a long time and its expensive. Thats a problem for cancer patients.

If someone has advanced cancer, you cant really wait that long, she said. Being able to build vaccines in a timely fashion is probably whats going to be needed to make this actually work. mRNA vaccines can be made lightning fast. All thats needed to create a new one is rewrite the genetic code in the vaccine. The Covid vaccine took only days to design once researchers had the novel coronaviruss genome. This could also be an advantage if the coronavirus mutates in a way that makes the current vaccines less effective.

The technology provides a nimble platform that you can switch things up quickly, Wu said.

Now that the Covid vaccine is being produced on a massive scale, Wu said, that might also help drive down some costs for the technology, as manufacturers find more efficient ways of making the mRNA. The last step remaining for cancer vaccines is to be tested in large clinical studies.

Thats true of other applications for modified mRNA, too. Wu pointed out that with two mRNA COVID-19 vaccines now in use, billions of dollars are going into the new technology. Other therapeutics arent likely to be too far behind.

This article was published by WBUR 90.9FM on Jan. 11. WBUR and the Reporter share content through a media partnership.

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Plumbing the marvels of 'mRNA' in creating vaccines, therapeutics - Dorchester Reporter

Key strategies in the global Plumbing Fixtures market like product developments, partnerships, mergers and acquisitions, etc., analysed in this report. The worth of strategic analysis has been rigorously investigated in conjunction with undisputed market challenges. The Plumbing Fixtures market report delivers conclusion that includes breakdown and data triangulation, consumer needs/customer preference change, research findings, market size estimation, data source. These factors will increase the business overall.

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If you are aiming to enter the Plumbing Fixtures business, this report is a comprehensive guide that provides crystal clear insights into this niche market. All the major application areas for Plumbing Fixtures are covered in this report and information is given on the important regions of the world where this market is likely to boom during the upcoming years, so that you can plan your strategies to enter this market accordingly. Besides, through this report, you can have a complete grasp of the level of competition you will be facing in this hugely competitive market and if you are an established player in this market already, this report will help you gauge the strategies that your competitors have adopted to stay as business leaders in this market. For new entrants to this market, the voluminous data provided in this report is invaluable.

Table of Content (TOC)

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In conclusion,the Plumbing Fixtures Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rates, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

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Plumbing Fixtures Market (2021-2026) | Potential growth, attractive valuation make it is a long-term investment | Geberit AG, Jacuzzi, Inc - The...

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Global Plumbing Hardware market is segmented based by type, application and region.

Plumbing Hardware Market Segmentation, By Type

Plumbing Hardware Market Segmentation, By Application

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

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Plumbing Hardware Market Size By Analysis, Key Vendors, Regions, Type and Application, and Forecasts to 2027 - NeighborWebSJ

Plumbing issues are frustrating and can cost a lot of time and money to fix. Some problems are too tricky and complicated to handle on your own, while others can be easily fixed with a few do-it-yourself tips. Plumbing issues such as clogged drains can undoubtedly disrupt your everyday activities, and you should always try to resolve your plumbing problems as soon as you can.

However, before you decide that you need a plumber, you should always determine what the plumbing issue you are having and whether or not you can tackle it on your own. Here is what you should always check first when you think you may need a plumber.

You can attempt to fix issues on your own such as leaking sinks, running toilets, and clogged drains. However, there are more challenging issues, such as burst pipes, and theres no question a professional plumber should handle that. Therefore, before you call a plumber, have a look at your issue and try to understand what the problem is and whether you have the knowledge and skills to solve it. If your sink is leaking, for example, you can try to fix it yourself by trying to identify any parts which have come loose and then try to tighten them up. Another common problem which many people have is a running toilet. To solve this issue, you can try to replace the flapper, the flapper valve, or both.

After you have assessed your plumbing problem and attempted all the home remedies to no avail, it is time to call a professional plumber. It is important that you hire a professional and trustworthy service to avoid wasting your time, money, and effort. Speak to friends and family for recommendations for local plumbers they have used in the past who have delivered a good service. The experts at All Service Plumbers explain that before hiring a plumber or giving them any money, you should check that they have a plumbing license and the necessary insurance to do the job. If you found the plumber on your own without a recommendation, it is advisable to go online to do some research or find at least two references. Additionally, you should check how long your chosen plumber has been in business since reputable businesses typically last for a longer time than unreliable ones.

Aside from leaking sinks and running toilets, clogged drains are among the most common plumbing problems people often face that are more difficult to fix at home. While major clogs often need a professional plumber, minor clogged drains are easier to deal with. In fact, you can try to check whether or not your sink is clogged by pouring water down and seeing if it drains.

If your sink is clogged, you can try different approaches, such as flushing your drain out using boiling water. This solution is the quickest, easiest, and most cost-effective way to solve a minor clog. First of all, you should try to remove the standing water in your sink or above the clogged area. After that, try pouring boiling water directly into the clogged drain. Wait for a moment to see whether the water goes down before removing the standing water and trying again.

Even though most people associate plungers with toilets, they can also be very effective with a clogged sink. Fill your sink with hot water up to a quarter of the way up, and then place a plunger over the plughole to work it up and down quickly. Afterward, remove the plunger from the drain and observe whether or not the water starts to drain. Remember that it might take some time and a few attempts for the plunger to unclog your sink successfully. Therefore, repeat this a few times if necessary. As well as a plunger, many people also use a straightened coat hanger to try and reach as far as possible down their clogged drains to fish out the blockage.

Depending on the blockage scale and the material which has built up, baking soda can be used with either white vinegar or salt to unblock the sink. Typically, all standing water should be removed from the blocked sink or the blocked area. Then, you can pour a mixture of baking soda and white vinegar or salt down the drain.

Note that this mixture might cause some bubbly liquid to rise, but if this happens, you can place a sink stopper on top of it or cover your drain with a piece of cloth. This solution should be left in your drain for 10 to 15 minutes before running boiling water down and attempting to flush out the drain.

If this doesnt do the trick, you can use a commercial solution made explicitly for blocked drains. This is widely available in many stores, and you can simply follow the instructions on the product. However, remember to use these solutions carefully to avoid physical harm to yourself or further damages.

It is helpful for you as a customer to get competing quotes on a plumbing issue that isnt too urgent. This allows you to choose the best quality plumbing service at a competitive price. Keep in mind; however, that price does not mean everything, and so the lowest price does not necessarily mean that you will get the best available service.

When a plumbing issue arises, sometimes the problem can be solved quickly with simple do-it-yourself tips and solutions. Other times, you will need to hire a professional plumber to save your plumbing system and home from further damage. However, before you call a plumber, remember to check these steps first to make sure that youre not calling one out for a job that you can easily do.

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What To Always Check When You're In Need Of A Plumber - E/The Environmental Magazine

Ed Del Grande, Tribune News Service Published 5:50 p.m. ET Dec. 3, 2020

Dear Ed: Enjoyed your plumbing gift article for the holidays. Especially like the rules: affordable, easy install and fun. But I noticed the gifts like musical showerheads were bathroom-related. Any kitchen plumbing gift ideas I can research?

Todd, Iowa

Dear Todd: Plumbing accessories can be fun gift choices. But my previously mentioned gifts were more bathroom-related, thanks for the catch. I've now come up with a few kitchen plumbing gift ideas to add to the holiday list.

1. Disinfecting wipes dispenser

These new stainless steel canisters look great on any kitchen countertop and can fit a standard 30-35 wipes inside.

This is a dedicated air dryer made especially for wine glasses. (Photo: David Wallace Kohler)

2. Kitchen sink utility racks

Improve the work area with these adjustable sink racks that straddle the sink bowl. Soaking cups, towel dryers and temporary shelving are just a few features.

3. Wine glass drying racks

This is a dedicated air dryer made especially for wine glasses. Wash, rinse and hang the glasses right next to the sink for fresh party supplies.

I hope these additional kitchen gift suggestions help you cook up some good presents for the holidays.

Master Contractor/Plumber Ed Del Grande is known internationally as the author of the book "Ed Del Grande's House Call," the host of TV and Internet shows, and a LEED green associate. Visiteddelgrande.comor writeeadelg@cs.com. Always consult local contractors and codes.

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The Plumber: Plumbing gifts that keep on giving - The Detroit News

SPRINGFIELD, Mo. A startup plumbing support company won $10,000 in an E-Factory pitch contest.

3D&L 3D-prints parts that help plumbers by holding pipes in place on the job.

Doug Harris, the owner of 3D&L, said his current product line makes the plumbing process easier by installing cross-linked polyethylene tubing.

Harris said he and his son bought 12 3D printers, figured out how to use them and started prototyping some things to use on the job to test them out.

Tests went on for about a year until three products were ready to be used every day.

Harris said he was very nervous with his pitch and described how he felt when he found out he had won.

Oh, man, are you kidding? I was like, oh yes, I got so many bills to pay, we got attorneys to pay for, getting our patents,' said Harris. Perfect timing. I was surprised we won. There were some really good, talented people doing that.

Harris said their initial intention wasnt just to start a company and make money but to make customers happy. The next step is to take the product nationwide.

For more information, visit https://www.3dandl.com/.

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Company wins contest for product geared to help plumbers - KOLR - OzarksFirst.com

GE Appliances Announces New Air & Water Solutions to Serve Plumbing and HVAC Industry | 2020-12-08 | ACHR News This website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more. This Website Uses CookiesBy closing this message or continuing to use our site, you agree to our cookie policy. Learn MoreThis website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more.

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GE Appliances Announces New Air & Water Solutions to Serve Plumbing and HVAC Industry - ACHR NEWS

Domonic John Evans admitted the offence when he appeared before Hereford Magistrates Court on December 2.

His white Audi Q1 was spotted in Hereford's Commercial Road at 9.30pm on November 4 after police were told he had driven away from a pub in the city, prosecutor Ralph Robyns Landricombe said.

Officers pulled up behind Evans, who they said checked to see if he was being followed by going around a roundabout and doubling back on himself.

The 32-year-old was pulled over in Stonebow Road, where officers noted a smell of alcohol on his breath, and was arrested after failing a roadside breath test.

In custody, an evidential test revealed Evans had 58 microgrammes of alcohol in 100 millilitres of breath. The legal limit is 35.

Edmund Middleton, for Evans, said the self-employed plumber had been having a very difficult year .

"He says Covid has had a big impact on his income," Mr Middleton said.

"Work has diminished significantly this year, which has caused a considerable amount of stress, and now he will be unable to drive to locations to work, the effect of this poor decision has been brought into sharp focus."

More court news:

The court heard a mandatory driving ban would mean Evans' teenage apprentice would also lose their job and would impact his family relationships.

"He is very regretful of his actions and apologises to the court for what has gone on," Mr Middleton said.

Evans, of Blaina, Abertillery, was disqualified from driving for 14 months, fined 120, and must pay a 34 victim surcharge. No costs order was made due to his means.

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Drink-drive plumber had been "having a very difficult year" - Hereford Times

How to Add Plumbing to Your Already Profitable HVAC Business | ACHR News This website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more. This Website Uses CookiesBy closing this message or continuing to use our site, you agree to our cookie policy. Learn MoreThis website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more.

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