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A new study sheds light on the mutations that control the color variations among rock pigeons.

The next time you spot a red pigeon, don't worry. It probably wasn't spray-painted. It's in the bird's genes.

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In a paper titled"Epistatic and Combinatorial Effects of Pigmentary Gene Mutations in the Domestic Pigeon"published this week in the journal Current Biology, a group of researchers from University of Utah say they have managed to crack the genetic code behind color variations among pigeons. The researchers identified mutations in three key genes Tyrp1, Sox10, and Slc45a2 that determine feather color in domestic rock pigeons.

"We were interested in understanding DNA level changes that give birth to specific traits among pigeons like, color of feathers," Michael Shapiro, associate professor of biology and senior author of the study told the Monitor.

The Tyrp1 gene produces an enzyme responsible for the synthesis of melanin and different forms of this gene that make pigeons blue-black (the grayish color of common city pigeons), ash-red, and brown, Dr. Shapiro said.

And mutations in another gene, named Sox10, make pigeons red irrespective of what other genes do. When Sox10, a recessive gene, mutates, it suppresses the Tyrp1gene, resulting in a bird with a really rich red color, he adds.

"You drop the baton and the orchestra doesn't play, " he says. "That is exactly what mutation in Sox10 does."

Sox10 is an example of an epistatic gene, one that obscures the effects of another gene.

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What makes a pretty pigeon? Scientists identify genes for feather colors.

Washington, Feb. 8 : Researchers have now sheds light on the role of genes and blood lipid levels in cardiovascular health.

Newer tools for gene analysis show how variations in DNA are underlying actors affecting heart diseasea"a major worldwide cause of death and disability.

Geneticist Brendan J. Keating, D. Phil., of The Center for Applied Genomics at The Children's Hospital of Philadelphia and his colleagues, working in large international collaborative groups, are wielding advanced gene-analysis tools to uncover important clues to heart disease.

The study team used a recently developed epidemiology tool called Mendelian randomization (MR).

The researchers analyzed DNA data from 17 studies including over 60,000 individuals, of whom more than 12,000 had experienced coronary heart disease, including heart attacks. Because previous studies had found signals from nearly 200 genes to be associated with blood lipid levels, the study team aggregated data into composite groups, called allele scores, for each of three blood lipids: LDL, HDL and triglycerides, then calculated their relationship to coronary heart disease.

As expected, the current study confirmed that higher levels of LDL, the "bad cholesterol," were more likely to cause heart disease. But there were new results: high levels of triglyceride also caused higher risk of heart disease. At the same time, there was little evidence that higher levels of HDL, the "good cholesterol," had a protective effect.

The study has been published in the European Heart Journal.

--ANI (Posted on 08-02-2014)

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Genetic signals could help reveal heart disease risk

Friday, February 7, 2014 10:52 PM EST

By JUSTIN MUSZYNSKI STAFF WRITER

BRISTOL The warrant for a man charged Friday in connection with the Joey Klett killing sheds new light on the last moments of the teenagers life.

Jordan Rutledge, 22, of 31 Summer St., was arrested Thursday for allegedly entering the house party that Klett was stabbed at and brandishing a revolver just after Klett ran out to get help.

The prosecutor said Friday at Rutledges arraignment in Bristol Superior Court that he does not believe he had anything to do with Kletts killing.

According to the warrant, multiple witnesses told police they saw an altercation between Klett and a man they only knew by an alias in the living room of 27 Irving St. around midnight Jan. 25.

Several people reported seeing a heavy-set black male in an argument with Klett that escalated to pushing and shoving. One witness said the altercation stemmed from the male telling Klett to stop staring at him.

Nathaniel Gonzalez, who went to the party with his brother, said the male pulled out a black knife before grabbing Klett and moving towards the door. He then said he heard a girl yell, they stabbed Joey, the warrant said.

He also told investigators that while Klett and the unknown male were fighting, a Hispanic male with corn row hair tried to hit Klett with a bottle. Gonzalez punched the man and ended up having the bottle smashed over his head.

Klett then ran out of the front door holding his stomach, witnesses said. It was at this point that a male, later identified as Rutledge, came in the front door waving a revolver around.

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Warrant sheds new light on stabbing incident

Charlotte investigating illegal dumping into Charlotte's water sewer system. (WSOC)

CHARLOTTE, N.C. (WSOC) The city of Charlotte is asking for the publics help in trying to find the person who illegally dumped chemicals into Mallard Creek.

Officials held a media briefing Friday morning to share details on the investigation into the illegal dumping.

City Manager Ron Carlee, Charlotte-Mecklenburg Utilities Director Barry Gullet, CFD Hazmat Deputy Jeff Dulin and CMPD Detective Rob Klass were in attendance.

Officials said that on Thursday, CFD hazmat crews responded to reports of an unusual substance flowing into the Mallard Creek Wastewater Treatment Plant on U.S. 29 North. An oily sheen could be seen on the surface of the water. The flow was contained in a holding tank until it was determined that it was safe to return the plant for service. The plant was back online Friday morning.

We worked through the night to make adjustments in the plant to be sure that we could handle the product and that we could produce safe and clean wastewater from the plant. So the plant, like Mr. Carlee said, is back online, and is functioning this morning, Gullett said.

The chemical has been identified as polychlorinated biphenyls or PCBs and trichlorobenzene. Officials said the citys water supply has not been affected by the illegal dumping and that this was an isolated incident in Mallard Creek.

Police think this is a case of illegal and deliberate dumping. They are asking anyone who may have seen anything suspicious late Wednesday evening or early Thursday morning near the Food Lion grocery store along Sugar Creek Road and W.T. Harris Boulevard to call police.

A Food Lion representative said the company is working closely with the City, EPA and other agencies to investigate the possibility of a third-party illegally dumping chemicals into a sewer drain near our Food Lion Store located at Sugar Creek Road and Harris Boulevard. Food Lion is working with authorities in the investigation to lead to the ultimate arrest of any and all individuals responsible for this situation.

The drinking water is safe, including the well water that many people in this area use, officials said, however they want people living along Mallard Creek south of the plant to be careful and avoid animal and human contact with the water until more tests can be done.

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Charlotte investigating illegal chemicals dumped into sewer system

EPHRATA Ephrata is looking how its septic system could serve heavy industry.

The city agreed to hire Gray and Osborne to review how well the sewer system could handle the waste from Lenroc. The Ephrata fertilizer company wants to connect to the citys system.

The $2,200 bill for the study will be paid by Lenroc, City Administrator Wes Crago said. The company is located at the north side of the port.

Theyve got a number of interesting chemical compounds that they work through, he said. They would like to see if its possible to use our sanitary sewer system to process their discharge.

City officials are concerned what chemicals would go into the citys wastewater treatment plant, and how they would affect it.

Before we can say, Yes or no, we need to have a study done about what we can accept and what they would need to pretreat, Crago said.

The study will give the city more information about what the sewer system can support. He said the sewer system at the port isnt designed for heavy industry.

This could give us some more knowledge (about) what we would need to do to make ourselves more postured for heavy industry, Crago said. (It would) definitely tell us what we can and cant do.

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Lenroc pays for study on how Ephrata system handles chemicals

CHARLOTTE, N.C.

The city of Charlotte is asking for the public's help in trying to find the person who illegally dumped chemicals into Mallard Creek.

Charlotte officials held a second media briefing at the government center Friday evening to update the public on the situation.

Charlotte Mayor Patrick Cannon said a lot of hard work has gone into rectifying the situation.

Anything coming out of your faucet is safe, Cannon said.

City officials are putting together a task force to find whoever is responsible for illegally dumping into sewer system.

The task force includes Charlotte Mecklenburg Utilities Department, Charlotte-Mecklenburg Police Department, Charlotte Fire Department, Environmental Protection Agency officials and North Carolina Highway Patrol.

Were talking about a time of the morning within the city at a time when the type of tanker truck that may be involved in something like this would be readily, hopefully identifiable by someone that may have seen it, said CMPD Chief Rodney Monroe.

Officials held their first media briefing Friday morning to share details on the investigation.

City Manager Ron Carlee, Charlotte-Mecklenburg Utilities Director Barry Gullet, CFD Hazmat Deputy Jeff Dulin and CMPD Detective Rob Klass were in attendance.

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Mayor on illegal dumping: 'Anything coming out of your faucet is safe'

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