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Jan. 17, 2014 New research from Queen Mary University of London has revealed -- for the first time -- how the condition Giant Cell Arteritis (GCA) may be caused by a certain group of white blood cells called 'neutrophils'. GCA (also known as temporal arteritis) is a condition which causes severe inflammation in the blood vessels and primarily affects the elderly.

GCA is initially treated with a six-month course of high-dose steroids. This study, published today in the journal Circulation Research, has shown that despite what appears to be signs of improvement following the treatment, the neutrophils become altered in a severe way that could lead to stroke or blindness.

This is the only study of its kind to investigate the role of neutrophils in relation to GCA and the discovery was made by comparing blood samples from patients suffering from vascular diseases. Patients with GCA, recruited to Southend University Hospital and Hammersmith Hospital, had blood samples taken within 48 hours of beginning steroid therapy, and again at 1, 4 and 24 weeks into treatment. Researchers examined these samples by isolating the neutrophils and studying its behaviour.

Mauro Perretti, lead author and Professor of Immunopharmacology, Queen Mary University of London, comments:

"We are very excited by this discovery and hope our findings will eventually lead to better clinical insight into whether a patient with GCA is really improving with treatment. It is commonplace for patients to come off therapy after six months but our research shows this may be too early for many. A GCA patient may appear to have recovered, but these findings reveal how changes and complications in the circulatory system could cause serious illness, such as stroke or even death.

We hope our study will lead to doctors monitoring the status of their patients' neutrophils in order to fully and truly assess disease progression and therapeutic control."

The research was a collaborative four-year effort led by Professor Mauro Perretti and colleagues Professor Bhaskar Dasgupta, Head of Rheumatology at Southend University Hospital, and Professor Justin Mason who leads on vascular Inflammation at Hammersmith Hospital.

In the UK, it is estimated that about one in every 4,500 people will develop a new case of giant cell arteritis each year. The condition is age-related and only tends to affect adults over the age of 50, and more commonly adults over 60 years old. The condition is three times more common in women than in men and it also seven times more common in white people than in black people.

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New discovery on Giant Cell Arteritis sheds light on cause

Consumers quest for the softest soft and the cleanest clean coupled with low-flow flushing is leading to costly, inconvenient clogs.

The new toilet paper, its bad news, says Paul Evan, owner of Ken Evans Plumbing and Heating Ltd. in Dartmouth.

I get the sales pitch that it is more comfortable, but toilet paper, it should never be that thick.

The plumber said his business has increased as toilet paper manufacturers have introduced increasingly more luxurious products and that is because the new multiply and super-strong tissues are tough on plumbing.

But the worst offenders, however, are the recently introduced wipes, which manufacturers claim are flushable, Evans said.

The new products are particularly tough on homes that have low-flow toilets and or old cast-iron pipes because the old metal pipes develop spurs that catch and snag the tissue and wipes, he explained, while low-flow toilets have less water pushing waste down the pipes.

So the paper, now, doesnt break down as much, its not being pushed down as far because it doesnt have enough water behind it. Thats what we found.

Evans recommended testing toilet paper at home to check for its flushability.

Take a couple pieces of that (ultra-thick) toilet paper and throw it into the bowl. If you look at it and wait, you will see that it wont break down. The cheaper stuff, you will see that it will basically shred itself.

And, even though some manufacturers are marketing flushable wipes for adults, Evans says they should go in the trash not the toilet.

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Plush paper puzzles plumbers

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LEXINGTON, Ky. (WKYT) - A Lexington man had to find another place to stay Friday night after a fire broke out in an addition to his home.

Firefighters were called to the home on Easthills Drive around 10:30 Friday evening. The homeowner told fire officials that he was downstairs originally and had gone upstairs to get something when he noticed the smoke and flames coming from his sun-room addition.

When crews arrived on the scene flames and smoke were visible from the home, and they were able to get the fire out fairly quickly. The fire did a large amount of damage to the addition on the home and the kitchen and dining room also sustained minor damage. Fire officials say they had to cut power to the home because they were unsure of the source of the fire.

According to fire officials there were no working smoke detectors in the home.

The cause of the fire is still under investigation but officials say they do not believe it is suspicious.

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Crews battle fire at Lexington home

SALEM - Area residents will have a couple of opportunities to tour the new private patient room tower at Salem Regional Medical Center next weekend, besides attending the tower dedication and the 100th Anniversary Time Capsule burial.

An open house geared toward families will be held from 10 a.m. to 2 p.m. Saturday, featuring activities and interactive attractions for children.

Another open house will be held from 2 to 5 p.m. next Sunday, kicking off with the tower dedication at 2 p.m. inside the concourse which connects the new section to the existing hospital structure.

The Salem Regional Medical Center is making plans for an open house this weekend. Area residents will have a couple of opportunities to tour the new private patient room tower besides attending the tower dedication and the 100th Anniversary Time Capsule burial. Open houses will be held from 10 a.m.-2 p.m. this Saturday and from 2-5 p.m. this Sunday. (Salem News photo by Patti Schaeffer)

The dedication will be followed by the burial of the 100th Anniversary Time Capsule outside at the front of the building next to the flag pole area.

"This is really a once in a lifetime opportunity to come into the hospital and see the largest addition we've ever put on this building," SRMC Director of Public Relations Michele Hoffmeister said.

The dedication ceremony will include remarks by SRMC President/CEO Anita Hackstedde, M.D. and SRMC Board Chairman Derek Hiscox, along with Pastor Robert Rowley, hospital chaplain, blessing the building.

WHAT: Community Open Houses.

WHERE: Salem Regional Medical Center.

WHEN: 10 a.m.-2 p.m. Jan. 25 & 2-5 p.m. Jan. 26.

Continued here:
SRMC’s big weekend includes dedication

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Stock Development has released for sale Phase II of Lakoya in Lely Resort. The second phase is the final single-family home neighborhood in Lely Resort.

Stock Development will be hosting a Grand Opening Weekend Event Feb. 22 and 23. This will be the first chance for the public to tour Lakoyas 16 new furnished models and the completion of a two-year expansion and renovation of the Players Club & Spa.

In Phase II of Lakoya, Stock is marketing 216 new homes, available in seven series of floor plans ranging from 1,882 to 4,155 square feet under air.

All of the homes will feature the extraordinary standard features packages that Stock is known for. Stock was named the 2013 Collier Building Industry Association (CBIA) Builder of the Year, the second time the company has won the award in the past five years. It is also a member of this years nationwide Builder 100 list and Lely Resort recently won its sixth consecutive Community of the Year Award from CBIA.

Lakoya has been an amazing success story, said Tim Clark, vice president of sales at Lely Resort. We have all of the homes under construction within Phase I and only a few homes remain. Several are available for immediate occupancy.

Lakoya is a meticulously planned 242-acre enclave with sculptured landscaping, classical gardens, choreographed fountains and paved walking paths. It is surrounded by subtropical woodlands and The Classics 18-hole golf course, which features gentle undulations and tree-lined fairways. An elaborate series of lakes has been crafted throughout the neighborhood, giving the homes an array of water, golf course and nature preserve views.

Lakoya residents have access to Naples most comprehensive amenities package. Lely Resort boasts three championship golf courses designed by some of the greatest architects in the game Robert Trent Jones Sr., Lee Trevino and Gary Player, as well as two golf clubhouses.

Stock is undertaking a two-year expansion plan that will dramatically increase the size of The Players Club & Spa. The Players Club & Spa provides an extraordinary value for nongolfers with an abundance of activities coordinated by a full-time staff. It has already completed 13 new tennis courts in the new Tennis Complex, as well as the new Spa & Fitness Center, which debuts this weekend.

Stocks expansion plan is nearing completion and greatly increases the size of the entire Players Club & Spa and ensure its amenity offerings are the most comprehensive to be found, said Melissa Speach, director of lifestyle. We are adding nearly 13,000 square feet under air to the existing structure. Work is nearing completion on a second resort pool.

The new pool is in addition to a 7,500-square-foot resort style swimming pool plus a 2,500-square-foot exercise and lap pool with cabanas. There is a new full kitchen at the Tiki Bar, which has seven 50-inch flat screen TVs and a tennis facility. A Bark Park is also open for the exclusive use of members who are dog owners.

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Sales underway in Phase II of Lakoya at Lely Resort

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