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Published: 2 Feb 2015 13:00

COLLEGE chiefs have been given 70,000 to study the future of the campus in Greenock with the Sugar Sheds touted as an alternative location.

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Bosses at the West College Scotland (WCS) Finnart Street facility have been given the sum from the Scottish Government to investigate the fabric of the building.

Local MSP Stuart McMillan has raised the issue on several occasions as to what support will be provided to make improvements.

The SNP man also mooted the idea of the college relocating to Greenocks historic Sugar Sheds to bring the building back into use should the Finnart Street campus be deemed no longer suitable.

Two years ago Mr McMillan wrote to the then James Watt College (JWC) management and various agencies, including the Scottish Funding Council (SFC) the governments higher and further education funding body calling for a feasibility study to be carried out to look into the idea.

The MSP is now happy that financial support to the tune of 70,000 has been provided to explore the future of the Greenock site.

Mr McMillan said: I am pleased to learn from the Scottish Government that funding of 70,000 has been provided to help undertake a business case outlining options for the Greenock campus.

Alongside this, the Scottish Government has invested 26.6 million of capital funding to the SFC to support infrastructure investment across the sector.

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Sugar Sheds touted as new college home

A new study involving researchers at The University of Nottingham has revealed how children with an aggressive cancer predisposition syndrome experience a never before seen flood of mutations in their disease in just six months.

The syndrome, called 'biallelic mismatch repair deficiency' (bMMRD) causes multiple brain tumours, lymphomas and gastrointestinal cancers by the age of 10. As a result these children rarely survive into adulthood.

While most cancers grow progressively, developing genetic mutations over many years, researchers at The Hospital for Sick Kids in Toronto, Canada, the Wellcome Trust Sanger Institute and the Children's Brain Tumour Research Centre in Nottingham, were shocked to find that children with this syndrome develop more mutations than any human cancers by far -- as many as 20,000 mutations in as little as six months.

The new paper, published online in Nature Genetics, suggests a previously undiscovered mechanism for cancer progression which could lead to more targeted treatment for these patients and indeed for more common cancers.

Children with biallelic mismatch repair deficiency, or bMMRD, have mutations in the genes responsible for mismatch repair and therefore cannot fix mistakes in DNA while the cell is dividing (or replicating). This study identifies a secondary mutation which occurs only in tumour cells in an enzyme called polymerase, which is a second safeguard that helps to effectively repair mutations while the DNA replicates. The combination of these two mutations leaves patients with no ability to repair mistakes that may occur while DNA is replicating, and causes a rapid wave of cancer that the investigators have dubbed the "great flood."

Professor Richard Grundy from the University's Children's Brain Tumour Research Centre said: "This study provides a major step forwards in understanding why certain children are more susceptible to developing multiple cancers and can screen for this eventuality. In turn, this study allows us to begin to understand the steps that lead to cancer developing. Ultimately, we hope this leads to treatments to avoid the presently inevitable consequences of this predisposition syndrome"

Dr Uri Tabori, co-principal investigator of the study from Genetics & Genome Biology at SickKids, Toronto said: "In other cancer predisposition syndromes like BRCA1 and Li Fraumeni syndrome, we know that there is a genetic mutation that predisposes the individual to cancer, but we do not know the secondary mutation, or genetic driver that actually causes the cancer to occur. Our findings indicate the genetic driver that causes this 'great flood' of cancer mutations in patients with bMMRD. The secondary mutation in the enzyme polymerase causes a unique signature of mutations that is present in 100 per cent of the cases. This has important implications for both diagnosis and targeted treatment of this devastating disease."

The Children's Brain Tumour Research Centre in Nottingham is part of an international consortium run by SickKids, Toronto, that offers free genetic testing, genetic counseling and surveillance of cancers in children and family members with bMMRD. Using genetic and clinical information and tumour samples gathered from each patient, the research team was able to take a deeper look at this cancer predisposition syndrome and for the first time they are able to tell the story of how this cancer develops.

"We were able to describe how many mutations develop, how fast they occur, how many mutations the tumour can sustain, and the type of mutation that occurs, which we found is unique to bMMRD cancers," says Dr Adam Shlien, lead author of the study and Associate Director of Translational Genetics and Scientist in Genetics & Genome Biology at SickKids.

"Additionally, by studying a rare cancer syndrome we were able to have an unobstructed view on how cancer develops and learn not only about how we can help these patients, but also about cancer progression in general."

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Study sheds new light on aggressive cancer in children

Date:

February 3, 2015

Source:

Max Planck Florida Institute for Neuroscience

Summary:

Using multiphoton imaging, researchers are now able to move beyond characterizing the properties of individual cells to investigate how communication among neurons changes over the course of development. In a new paper, researchers report substantial developmental changes in communication among cells that significantly improve the information processing capabilities of the brain.

Previous work, including studies performed in the Fitzpatrick Lab at MPFI, has shown that individual brain cells refine their responses to stimuli with experience so they can better discriminate between similar features in their environments. However, the signals of individual brain cells can be noisy and imprecise which means our brains cannot rely solely on the activity of single neurons to make accurate decisions about our world. Instead, we combine the activity of thousands to millions of neurons to ensure a more accurate message, which makes effective communication amongst large populations of neurons a central feature of the brain.

This study demonstrates that, over development, neural circuits reorganize themselves to decrease noise and improve the fidelity of communication amongst each other. The critical role these changes play in brain development highlights the importance and urgency in understanding neural circuits in more detail and suggests new avenues for investigating the underlying causes of developmental disorders such as autism.

The authors of the study said the key question moving forward is to understand what specific changes in brain circuitry give rise to the effects observed in this study. Where do these changes manifest themselves within the circuit and what molecular processes do they utilize? We know that a number of structural changes also occur during this developmental period, and we now can attempt to link those changes to the changes in circuit function.

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New research sheds light on neural circuit development

Bought by Columbus Nova, Sony Online Entertainment becomes an independent game development studio

Sony has sold Sony Online Entertainment, an Internet games company it established in the 1990s, to investment firm Columbus Nova.

SOE has been renamed Daybreak Game Company and will operate as an independent game development studio producing titles for the PlayStation and Xbox, according to a statement on its forum.

"All of our games are still here and will continue to be," Daybreak president John Smedley wrote in a message on Twitter, adding that the company is still working on EverQuest Next, the latest sequel to 1999's EverQuest, a massively multiplayer online role-playing game (MMORPG).

With an emphasis on PC games, the company had been in the shadow of Sony's more popular video game hardware business including the hit PlayStation 4 console, as well as the recent rise of games for mobile platforms.

"We determined it was in the best interest of both entities to allow the studio to realize its full potential as a multi-platform online gaming company," Sousuke Kamei, a spokesman at Sony's Tokyo headquarters, said via email.

"The environment surrounding the game industry is always challenging, and we are doing a review of our business on a regular basis. As part of it, we decided to sell SOE for strengthening the overall business quality in order to increase higher profitability," Kamei said.

SOE is the latest business to be shed by the struggling manufacturer, which sold its Vaio PC business and pulled out of e-readers last year.

Tim Hornyak covers Japan and emerging technologies for The IDG News Service. Follow Tim on Twitter at @robotopia.

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Sony sheds online game unit known for EverQuest

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This curved tunnel beneath Homestead Avenue, in Hartford's North End, is part of The Metropolitan District Commission's Clean Water Project for separating its storm drains and septic-sewer channels. The project will improve the quality of treated wastewater before it winds up in Connecticut's inland waterways and Long Island Sound.

The State Bond Commission on Friday approved $480 million in grants and loans to wastewater projects in Hartford, Bristol, Norwich, and more statewide.

The Metropolitan District Commission received $80 million in grants and $178 million in loans for a 20-year investment in Greater Hartford to separate the flow of stormwater from sanitary sewers.

The Bristol Wastewater Treatment plant received $9.5 million in grants and $9.5 million in loans for various upgrades, including removing phosphorous from wastewater in order to protect the Pequabuck River.

The Norwich Wastewater Treatment Plants received $20 million in grants and $80 million in loans to upgrade its infrastructure and nitrogen removal.

The remaining $103 million will be used for a variety of projects across the state, including planning studies, engineering designs, and green infrastructure projects, including compensating for sea level rise.

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CT approves $480M for wastewater projects

14 Suffolk Street, Pembroke, MA
Meticulously maintained Gambrel Cape w/large family room addition with vaulted ceiling, skylights, and wood ceiling. Sliders to large 3 season room w/hot tub, ceramic tile floor and sliders...

By: Larry Meredith Hunt, The Hunt Team

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14 Suffolk Street, Pembroke, MA - Video

Niceville residents J.V.O. and Sharon Weaver stroll down the boardwalk at Turkey Creek Nature Trail on Monday. The boardwalk follows the creek from a pavilion next to John Sims Park-way 3/4 of a mile north.

NICEVILLE Fans of the Turkey Creek Nature Trail boardwalk will soon have even more room to roam.

Beginning in late February/early March, construction will begin on an addition that will connect two separate sections of walkway.

Currently, the section of the park with its entrance on John Sims Parkway has approximately of a mile of boardwalk that is enjoyed by walkers, joggers and swimmers headed for a dip in the creek. The other section of the park, whose entrance is located off of College Boulevard, includes approximately 900 feet of boardwalk. Both sections feature pavilions and picnic tables.

It will take about 320 feet of new boardwalk to connect the two sections, giving park visitors nearly a full mile of walking and jogging space. The addition is expected to take about three months.

If all goes well, we hope to get started soon, and have the addition finished by summer, said Willie Hines, the citys repair and maintenance foreman.

Visitors to the park on Monday were happy to hear that work on the addition will begin soon.

I think its wonderful, said Niceville resident Michelle Tew, who walks the length of the boardwalk and back at least once a day and sometimes twice. This is such a beautiful place to walk, and Ive been looking forward to the new section.

Crestview residents Debbie and Burl Olson are also frequent visitors.

Im happy to hear that, Burl said. We try to walk about two miles a day, so the addition will put the length right in our wheelhouse.

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Turkey Creek to see improvements

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Following "Coyotes" and "Lampshades on Fire," Modest Mouse have a new track out titled "The Best Room." Showcasing Isaac Brock's signature choppy vocals, the penultimate track on the forthcoming Strangers to Ourselves decries the deteriorating state of Western civilization, crowing, "The lessons unlearned, oh this meeting it's adjourned! / These western concerns, 'Hold my place in line while I take your turn.'"

In addition to the new song, the guys announced plans to push the release of their album back to March 17, which is a bummer, but to help make up for things they released the album's track list, which you can see below. Hear "The Best Room" above.

Modest Mouse, Strangers to Ourselves track list: 1. "Strangers To Ourselves" 2. "Lampshades On Fire" 3. "Shit In Your Cut" 4. "Pistol (A. Cunanan, Miami, FL. 1996)" 5. "Ansel" 6. "The Ground Walks, With Time In A Box" 7. "Coyotes" 8. "Pups To Dust" 9. "Sugar Boat" 10. "Wicked Campaign" 11. "Be Brave" 12. "God Is An Indian And Youre An Asshole" 13. "The Tortoise And The Tourist" 14. "The Best Room" 15. "Of Course We Know"

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The Lists The Top 100 Alternative Albums of the 1960s

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Stream Modest Mouse's Political New Track, 'The Best Room'

Kevin C. Cox/Getty Images Robert Griffin III reportedly has some personal issues with his teammates.

By Larry Brown

The NFL season has finally ended, which means its time for NFL writers to do what they do best: criticize easy targets. Its no surprise that the columns about Robert Griffin III have already started.

The Washington Posts Jason Reidchecked in with a column Mondayabout RG3s personality. The crux is that the quarterback isnt one of the boys and that hurts his ability to be a leader.

Heres what Reid wrote:

(Tim) Brown said publicly what some of Washingtons coaches and players have shared with me privately: Griffins aloofness has been an issue in the locker room. Combine that with Griffins poor performance the past two seasons and a Super Bowl-sized ego that tripped him up after his magical rookie year, and its clear Griffin isnt close to becoming the player the Redskins need him to be.

Reids writing was inspired mostly by comments Tim Brown, who was on the radio Thursday to promote his Hall of Fame candidacy.

Brown has interacted with Griffin during Heisman Trophy gatherings andshared some insight on Griffins character.

But I know RGIII well enough to know that hes a little different, Brown said on ESPN 980 last week. I mean, I know he is maybe not the brother that youre gonna be hanging out in the locker room with. And from that standpoint, thats something that he has to work on. If hes going to be a leader, he has to be a leader of everybody in the locker room, and not just one or two guys in the locker room.

Brown also said that Griffin has a hard time joking around with the other Heisman winners, which leads him to be an outcast. Brown suggests Griffin should loosen up in order to relate better to his teammates.

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RG3's 'aloofness' in locker room an issue for Redskins?